个人简介
2014 Lecturer in Virus/Host Interactions
Department of Microbial & Cellular Sciences. University of Surrey
2011-2013 Post-doctoral Researcher. PI: Prof. Geoffrey L. Smith
Department of Pathology. University of Cambridge
2009-2011 Post-doctoral Fellow. PI: Prof. Geoffrey L. Smith
Department of Virology. Imperial College London
2008-2009 Post-doctoral Researcher. PI: Dr. Claude Krummenacher
Department of Biochemistry. University of Pennsylvania
2007-2008 Research Assistant Professor. PI: Prof. Rosina Girones
Department of Microbiology. University of Barcelona
2007 Ph.D. PI: Prof. Rosina Girones
Department of Microbiology. University of Barcelona
研究领域
Viruses are intracellular parasites that have co-evolved with life for millions of years. Some viruses are the cause of common, and sometimes lethal, diseases in humans and animals. My laboratory is interested in how double-stranded DNA viruses (group I of the Baltimore classification) interact with the host cell and manipulate the host immune response to propagate and cause pathogenesis. In particular, we study poxviruses and herpesviruses as models to understand viral immune evasion and alteration of cellular signalling. These viruses have large coding capacity and display a wide range of strategies to interfere with the infected cell. Elucidating such strategies teaches us about the viral life cycle itself and the host anti-viral response, and has the potential to identify targets for anti-viral interventions and improve the rational design of viral vectors for vaccine and oncolytic therapies.
近期论文
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Neidel S, Maluquer de Motes C, Mansur DS, Strnadova P, Smith GL, Graham SC. (2015) 'Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family.'. J Biol Chem, United States: 290 (10), pp. 5991-6002. doi: 10.1074/jbc.M114.624650
Ren H, Ferguson BJ, Maluquer de Motes C, Sumner RP, Harman LE, Smith GL. (2014) 'Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor.'. Immunology, England: 145 (1), pp. 34-49. doi: 10.1111/imm.12422
Veyer DL, Maluquer de Motes C, Sumner RP, Ludwig L, Johnson BF, Smith GL. (2014) 'Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection.'. J Gen Virol, England: 95 (Pt 12), pp. 2757-2768. doi: 10.1099/vir.0.068833-0
Maluquer de Motes C, Schiffner T, Sumner RP, Smith GL. (2014) 'Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues.'. J Gen Virol, England: 95 (Pt 9), pp. 2038-2049. doi: 10.1099/vir.0.065664-0