Gerber, Andre - University of Surrey - School of Biosciences and Medicine

个人简介

André studied Biochemistry at the University of Zurich and obtained a PhD in Cell Biology from the University of Basel for his work on adenosine deaminases acting on RNA. He completed post-doctoral studies in the laboratories of Dan Herschlag and Pat Brown at Stanford University, where he started to explore RNA-protein interactions on a genome-wide scale. During 2004-2011, he was an independent research group leader at the ETH Zurich, studying RNA-protein interactions with genomics and proteomics means in different model organisms. Since 2012 he is Professor of RNA biology at the Faculty of Health and Medical Sciences, University of Surrey, UK.

研究领域

We explore global and specific aspects of post-transcriptional gene regulation mediated by RNA-binding proteins and non-coding RNAs. Gene expression must be tightly controlled to ensure coordinated synthesis of the cells’ macromolecular components. Besides transcriptional control, it has become evident that also the later post-transcriptional steps – namely the processing, transport, turnover and translation of mRNAs – are pivotal for the diversification and spatiotemporal control of gene expression. Hundreds of RNA-binding proteins and non-coding RNAs mediate post-transcriptional control with widespread implications in cell physiology and disease. Nevertheless, the targets and functions for most RNA-binding proteins and non-coding RNAs are still not known. We have been combining genome-wide analysis with classical biochemical and genetic tools to identify the RNA targets of RNA-binding proteins and to investigate post-transcriptional gene regulation on a global scale. Importantly, these studies revealed that RNA-binding proteins bind to and coordinate groups of mRNAs that code for proteins, which are localized to the same subcellular compartment, act in the same pathway or are components of macromolecular complexes, forming so-called RNA regulons. Moreover, these set of RNAs often bear conserved sequence/ structural elements that likely represent binding sites for RNA-binding proteins. These findings suggested the presence of a highly-organized and elaborate post-transcriptional regulatory system that may affect virtually every mRNA in a cell. We are further exploring the post-transcriptional regulatory landscape. On the one hand, we study specific RNA-binding proteins that coordinate the localization, decay or translation of mRNAs in the cytoplasm. On the other hand, we characterize the translatome – which refers to all mRNAs that are associated with ribosomes for protein synthesis (Halbeisen et al. 2009) – and we monitor its reaction upon stress or drug treatment of cells and in pathological conditions. We primarily use budding yeast as model to establish new techniques and to elucidate principles of post-transcriptional control, and we work with mammalian cells to unravel implications in disease.

近期论文

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Matia-González AM, Iadevaia V, Gerber AP. (2016) 'A versatile tandem RNA isolation procedure to capture in vivo formed mRNA-protein complexes'. Elsevier Methods, doi: 10.1016/j.ymeth.2016.10.005 Subasic D, Stoeger T, Eisenring S, Matia-González AM, Imig J, Zheng X, Xiong L, Gisler P, Eberhard R, Holtackers R, Gerber AP, Pelkmans L, Hengartner MO. (2016) 'Post-transcriptional control of executioner caspases by RNA-binding proteins'. Cold Spring Harbor Laboratory Press. Genes and Development, 30, pp. 2213-2225. doi: 10.1101/gad.285726.116 Matia-González AM, Laing EE, Gerber AP. (2015) 'Conserved mRNA-binding proteomes in eukaryotic organisms.'. Nature structural & molecular biology, 22 (12), pp. 1027-1033.