Dunn-Walters, Deborah - University of Surrey - School of Biosciences and Medicine

个人简介

Deborah Dunn-Walters is Professor of Immunology in the School of Bioscience and Medicine, Faculty of Health and Medical Sciences. Her group studies B cell development in Health and Disease, taking a systems immunology approach to elucidate changes in humoral immunity with age and to discover antibodies useful in cancer and infectious disease. She was the first to use high throughput sequencing of immunoglobulin repertoires to determine changes in repertoire between different types of B cells and to show that the B cell repertoire is compromised with age. She has over 90 publications and currently holds major grant funding from the MRC and BBSRC. In addition she is extremely grateful to the Dunhill Medical Trust, The Human Frontiers Science Programme, Research into Ageing and the Rosetrees Trust for supporting her research.

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Martin VG, Wu Y-CB, Townsend CL, Lu GH, O'Hare JS, Mozeika A, Coolen AC, Kipling D, Fraternali F, Dunn-Walters D. (2016) 'Transitional B cells in early human B cell development - time to revisit the paradigm?'. Frontiers Media Frontiers in Immunology, 7, pp. 546-546. doi: 10.3389/fimmu.2016.00546 Townsend CL, Laffy JMJ, Wu Y-C, O’Hare JS, Martin V, Kipling D, Fraternali F, Dunn-Walters D. (2016) 'Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions'. Frontiers Media Frontiers in Immunology, doi: 10.3389/fimmu.2016.00388 Laffy JMJ, Dodev T, Macpherson JA, Townsend C, Lu HC, Dunn-Walters D, Fraternali F. (2016) 'Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back'. Elsevier Progress in Biophysics and Molecular Biology, doi: 10.1016/j.pbiomolbio.2016.09.002