Blackbourn, David J. - University of Surrey - School of Biosciences and Medicine

个人简介

David J. Blackbourn is Professor and Head of the School of Biosciences and Medicine, Faculty of Health and Medical Sciences. His group studies viruses that are responsible for causing cancer. In particular, his interests lie in how such viruses cause disease, evade the immune response and interact with the DNA damage response. Prof Blackbourn has published over 70 research papers and reviews in virology and immunology. He has received major grant funding from Cancer Research UK, The Wellcome Trust, the MRC, BBSRC and the Royal Society. He is a Fellow of the Society of Biology (FSB). 1/8/2013 Head of Department of Microbial and Cellular Sciences, University of Surrey 1/8/2013 Honorary Senior Research Fellow, School of Cancer Sciences, University of Birmingham 1/10/2010 Professor of Virology, University of Birmingham

研究领域

Infectious agents, including viruses, are associated with up to 20% of human cancers. The Blackbourn laboratory studies two such viruses: Kaposi's sarcoma-associated herpesvirus (KSHV) and Merkel cell polyomavirus (MCV or MCPyV). Our major interest is in how viruses cause disease and modulate the immune response. KSHV provides a model for most of our studies, but the impact of our work could extend to other viruses or host/pathogen interactions. Our main research topics in this context are: (i) how KSHV interacts with the DNA damage response. (ii) How KSHV modulates the type I interferon (alpha & beta) response. (iii) How KSHV deregulates antigen-specifc T cell responses. (iii) What are the consequences of KSHV infection on endothelial cell biology, including cell-cell interactions and regulating leukocyte recruitment.   For MCV, our interests lie in understanding the tumour microenvironment and how it contributes to the pathogenesis of Merkel cell carcinoma.

近期论文

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Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ. (2015) 'Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.'. Viruses, Switzerland: 7 (6), pp. 2908-2927. doi: 10.3390/v7062752 Amini AA, Solovyova AS, Sadeghian H, Blackbourn DJ, Rezaee SA. (2014) 'Structural properties of a viral orthologue of cellular CD200 protein: KSHV vOX2.'. Virology, United States: 474, pp. 94-104. doi: 10.1016/j.virol.2014.10.020 Knight LM, Stakaityte G, Wood JJ, Abdul-Sada H, Griffiths DA, Howell GJ, Wheat R, Blair GE, Steven NM, Macdonald A, Blackbourn DJ, Whitehouse A. (2014) 'Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration.'. J Virol, United States: 89 (1), pp. 35-47. doi: 10.1128/JVI.02317-14 Othman Z, Sulaiman MK, Willcocks MM, Ulryck N, Blackbourn DJ, Sargueil B, Roberts LO, Locker N. (2014) 'Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation.'. RNA, United States: 20 (11), pp. 1803-1814. doi: 10.1261/rna.045328.114