Mikolajek, Halina - University of Southampton - Discipline of Biological Sciences

个人简介

Career history Postdoctoral Research Fellow in X-ray Crystallography and NMR, University of Southampton, UK. Postdoctoral Research Fellow in X-ray Crystallography, University College London, UK. Academic qualifications PhD in X-ray Crystallography. University of Southampton, UK. BSc in Biochemistry with Physiology. University of Southampton, UK.

研究领域

My research interests revolve around protein structure and ligand interactions. To understand the function and structure of specific proteins, I combine three different techniques: Nuclear Magnetic Resonance (NMR), X-ray crystallography and Isothermal titration Calorimetry (ITC). These studies are providing us with an insight into how these proteins interact, are regulated and work.

近期论文

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Molecular mechanism for the control of eukaryotic elongation factor 2 kinase by pH: role in cancer cell survival - Xie, Jianling, Mikolajek, Halina, Pigott, Craig R., Hooper, Kelly J., Mellows, Toby, Moore, Claire E., Mohammed, Hafeez, Werner, Jörn M., Thomas, Gareth J. and Proud, Christopher G. Published:2015Publication:Molecular and Cellular BiologyVolume:35, (10)Page Range:1805-1824doi:10.1128/MCB.00012-15PMID:25776553 Elongation Factor 2 Kinase is regulated by Proline Hydroxylation and protects cells during Hypoxia - Moore, Claire E.J., Mikolajek, Halina, Regufe da Mota, Sergio, Wang, Xuemin, Kenney, Justin W., Werner, Jörn M. and Proud, Christopher G. Published:2015Publication:Molecular and Cellular BiologyVolume:35, (10)Page Range:1788-1804doi:10.1128/MCB.01457-14PMID:25755286 Characterization of recombinantly expressed matrilin VWA domains - Becker, Ann-Kathrin A., Mikolajek, Halina, Werner, Jörn M., Paulsson, Mats and Wagener, Raimund Published:2015Publication:Protein Expression and PurificationVolume:107Page Range:20-28doi:10.1016/j.pep.2014.11.005 Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator - Phippen, Curtis William, Mikolajek, Halina, Schlaefli, Henry George, Keevil, Charles William, Webb, Jeremy Stephen and Tews, Ivo Published:2014Publication:FEBS LettersVolume:588, (24)Page Range:4631-4636doi:10.1016/j.febslet.2014.11.002 A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity - Moore, C. E., Regufe da Mota, S., Mikolajek, H. and Proud, C.G. Published:2014Publication:Molecular and Cellular BiologyVolume:34, (12)Page Range:2294-2307doi:10.1128/MCB.00388-14PMID:24732796