Mancuso, Renzo - University of Southampton - Discipline of Biological Sciences

个人简介

Career History 2015-Present: Postdoctoral research fellow. University of Southampton, UK. 2010-2014: PhD in Neuroscience. Autonomous University of Barcelona (UAB), Spain. 2009-2010: Master in Neuroscience. Autonomous University of Barcelona (UAB), Spain. 2005-2009: Undergraduate student in Biology. Autonomous University of Barcelona (UAB), Spain. Academic Qualifications 2014: PhD in Neuroscience. . Autonomous University of Barcelona (UAB), Spain. 2010: Master in Neuroscience. Autonomous University of Barcelona (UAB), Spain. 2009: Degree in Biology. Autonomous University of Barcelona (UAB), Spain.

研究领域

My research interests are focused on the neuroinflammatory events taking place in chronic neurodegenerative diseases, including Alzheimer’s and prion. Our main goal is to address how microglial cells contribute to these pathologies and to test the efficacy of innovative therapeutic approaches in modulating markers of central inflammation.

近期论文

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Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation - Clayton, E.L., Mancuso, R., Nielsen, T.T., Mizielinska, S., Holmes, H., Powell, N., Norona, F., Larsen, J.O., Milioto, C., Wilson, K.M., Lythgoe, M.F., Ourselin, S., Nielsen, J.E., Johannsen, P., Holm, I., Collinge, J., Frej, A., Oliver, P.L., Gomez-Nicola, D. and Isaacs, A.M. Published:2017Publication:Human Molecular GeneticsPage Range:1-40doi:10.1093/hmg/ddx003 CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves - Martinez-Muriana, Anna, Mancuso, Renzo, Francos-Quijorna, Isaac, Olmos-Alonso, Adrian, Osta, Rosario, Perry, Hugh, Navarro, Xavier, Gomez-Nicola, Diego and Lopez-Vales, Ruben Published:2016Publication:Scientific ReportsVolume:6, (25663)Page Range:1-13doi:10.1038/srep25663PMID:27174644 Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology - Olmos-Alonso, A., Schetters, S.T.T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V.H. and Gomez-Nicola, D. Published:2016Publication:BrainPage Range:1-17doi:10.1093/brain/awv379PMID:26747862 Pre-symptomatic electrophysiological tests predict clinical disease onset and survival in SOD1G93A ALS mice - Mancuso, R., Osta, R. and Navarro, X. Published:2014Publication:Muscle & NerveVolume:50, (6)Page Range:943-949doi:10.1002/mus.24237PMID:24619579 Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G?³A ALS mice: overlapping effects or limited therapeutic opportunity? - Mancuso, Renzo, Del Valle, Jaume, Morell, Marta, Pallás, Mercé, Osta, Rosario and Navarro, Xavier Published:2014Publication:Orphanet Journal of Rare DiseasesVolume:9Page Range:78-89doi:10.1186/1750-1172-9-78PMID:21896316