Lane, Simon I.R. - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2013-present: Research Fellow. University of Southampton, UK. 2012-2013: Research Fellow. University of Newcastle, UK. Academic qualifications 2009-2012: PhD Human Physiology. University of Newcastle, Australia. 2005-2008: BSc Human Physiology (Hons I). University of Newcastle, UK.

研究领域

I completed my undergraduate degree in Newcastle upon Tyne before heading to another Newcastle, this time in Australia to undertake a PhD. There I wrote my thesis on chromosome division in oocytes, a highly specialised division with clinical relevance to the origin of trisomies (like Down Syndrome) and to miscarriage. In Newcastle I developed techniques for automated, 3D imaging of cells expressing multiple fluorescently-tagged proteins using timelapse microscopy. Now in Southampton I use this approach to track the movements and destruction of various proteins throughout the cell cycle, helping to further our understanding of the molecular mechanisms behind chromosome segregation.

近期论文

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The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis - Hamdan, Mukhri, Jones, Keith, Cheong, Ying and Lane, Simon Published:2016Publication:Scientific ReportsVolume:6, (36994)Page Range:1-8doi:10.1038/srep36994PMID:27841311 FACS-sorted putative oogonial stem cells from the ovary are neither DDX4-positive nor germ cells - Zarate-Garcia, Larissa, Lane, Simon I.R., Merriman-Jones, Julie A. and Jones, Keith T. Published:2016Publication:Scientific ReportsPage Range:1-28 DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint - Collins, Josie, Lane, Simon, Merriman-Jones, Julie and Jones, Keith Published:2015Publication:Nature CommunicationsVolume:6, (8553)Page Range:1-12doi:10.1038/ncomms9553PMID:26522232 Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice. - Yun, Y, Holt, JE, Lane, SIR, McLaughlin, EA, Merriman, JA and Jones, KT Published:2014Publication:Cell CycleVolume:13, (12)Page Range:1-10PMID:24758999 Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes - Yun, Y, Lane, SIR and Jones, KT Published:2014Publication:Development Volume:141, (1)Page Range:199-208doi:10.1242/dev.100206 Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes - Lane, SIR and Jones, KT Published:2014Publication:Nature CommunicationsVolume:5Page Range:3444doi:10.1038/ncomms4444