Calahorro, Fernando - University of Southampton - Discipline of Biological Sciences

个人简介

As neurobiologist I am interested in animal behavioural plasticity and this led me to focus on neuroligin and neurexin, two synaptic proteins that appear essential to integrate sensory input to produce appropriate behavioural output and which are disrupted in autism spectrum disorders (ASD). I established collaboration with Professor Holden-Dye and O’Connor, and I have shown an evolutionary conservation of the neuroligin-neurexin axis from the nematode worm Caenorhabditis elegans through to human. This may extend to functional conservation of a core synaptic code that is implemented to organise animal behaviour. As the C. elegans nervous system is built on the same principles as the human it provides a genetically and behaviourally tractable model to study neurexin/neuroligin with potential relevance to ASD.

研究领域

C. elegans synapse as a model in synaptophaties. - Neuroligin/neurexin trans-synaptic modelling. - Molecular Genetics of Autism. The synaptopathies are responsible for complex disorders like schizophrenia and autism and emerge in the brain when individual genes are disrupted. Within these genes are neuroligins (NLGNs) and neurexins (NRXNs).

近期论文

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In vivo and in vitro studies of the role of lyophilised blond Lager beer and some bioactive components in the modulation of degenerative processes - Merinas-Amo, Tania, Tasset-Cuevas, Inmaculada, Díaz-Carretero, Antonio M., Alonso-Moraga, Ángeles and Calahorro , Fernando Published:2016Publication:Journal of Functional FoodsVolume:27Page Range:274-294doi:10.1016/j.jff.2016.09.014 Chemical activation of a food deprivation signal extends lifespan - Lucanic, Mark, Garrett, Theo, Yu, Ivan, Calahorro Nunez, Fernando, Asadi Shahmirzadi, Azar, Miller, Aaron, Gill, Matthew S., Hughes, Robert E., Holden-Dye, Linda and Lithgow, Gordon J. Published:2016Publication:Aging CellVolume:15, (5)Page Range:832-841doi:10.1111/acel.12492 Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans. - Dillon, James, Franks, Christopher J, Murray, Caitriona, Edwards, Richard J, Calahorro, Fernando, Ishihara, Takeshi, Katsura, Isao, Holden-Dye, Lindy and O'Connor, Vincent Published:2015Publication:The Journal of Biological ChemistryPage Range:1-28doi:10.1074/jbc.M114.606608PMID:25869139 Analysis of splice variants for the C.?elegans orthologue of human neuroligin reveals a developmentally regulated transcript - Calahorro, Fernando, Holden-Dye, Lindy and O'Connor, Vincent Published:2015Publication:Gene Expression PatternsVolume:17, (2)Page Range:69-78doi:10.1016/j.gep.2015.02.002PMID:25726726