Williamson, Philip - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2007-present: Lecturer. University of Southampton, UK. 2007-2011: Wellcome Trust Career Development Fellowship. University of Southampton, UK. 2005-2007: Charge de Recherche. CNRS/ULP-Strasbourg, France. Academic qualifications 2000-2005: Post-doctoral Fellow. ETH-Zurich, Switzerland, UK. 1995-2000: DPhil in Biochemistry. University of Oxford, UK. 1991-1995: BA (Hons), MA, Biochemistry Department, University of Oxford.

研究领域

Molecular interactions in biological membranes Biological membranes are ubiquitous in nature and play a vital role in defining the interface of the cell with its environment and its intracellular compartmentalisation. In order to facilitate the transfer of information and materials across these barriers cells have evolved families of integral membrane proteins. The goal of our research is to understand the function of these proteins in their native lipid environment and for this purpose; we are developing solid-state NMR techniques which enable us to probe the structure and dynamics of these systems at an atomic level. In conjunction with other biophysical techniques, this method allows us to characterise how membrane proteins interact with other proteins, the surrounding lipids and other small molecules and to determine how these interactions modulate their function. Recognition of small molecules by integral membrane receptors The regulation of many integral membrane receptors is mediated through their interaction with small molecules. Our studies on the nicotinic acetylcholine receptor have enabled us to identify interactions involved in ligand binding and determine the conformation of the bound agonist, acetylcholine. Currently we are developing further solid-state NMR techniques to analyse how hydrophobic ligands such as anaesthetics may interact with the nicotinic acetylcholine receptor and aid in the rational development of pharmaceuticals against both this and other classes of membrane proteins.

近期论文

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Magnetically oriented bicelles with monoalkylphosphocholines: versatile membrane mimetics for nuclear magnetic resonance applications - Beaugrand, Maïwenn, Arnold, Alexandre A., Juneau, Antoine, Gambaro, Aline Balieiro, Warschawski, Dror E., Williamson, Philip T.F. and Marcotte, Isabelle Published:2016Publication:LangmuirVolume:32, (49)Page Range:13244-13251doi:10.1021/acs.langmuir.6b03099PMID:27951690 A mirror code for protein-cholesterol interactions in the two leaflets of biological membranes - Fantini, Jacques, Di Scala, Coralie, Evans, Luke S., Williamson, Philip T.F. and Barrantes, Francisco J. Published:2016Publication:Scientific ReportsVolume:6, (21907)Page Range:1-14doi:10.1038/srep21907PMID:26915987 C60fullerene localization and membrane interactions in RAW 264.7 immortalized mouse macrophages - Russ, K.A., Elvati, P., Parsonage, T.L., Dews, A., Jarvis, J.A., Ray, M., Schneider, B., Smith, P.J.S., Williamson, P.T.F., Violi, A. and Philbert, M.A. Published:2016Publication:NanoscaleVolume:8, (7)Page Range:4134-4144doi:10.1039/c5nr07003a 14N overtone transition in double rotation solid-state NMR - Haies, Ibraheem M., Jarvis, James A., Brown, Lynda J., Kuprov, Ilya, Williamson, Philip T. F. and Carravetta, Marina Published:2015Publication:Physical Chemistry Chemical PhysicsVolume:17, (37)Page Range:23748-23753doi:10.1039/C5CP03266K Interaction between the NS4B amphipathic helix, AH2, and charged lipid headgroups alters membrane morphology and AH2 oligomeric state — Implications for the Hepatitis C virus life cycle - Ashworth Briggs, Esther L., Gomes, Rafael G.B., Elhussein, Malaz, Collier, William, Stuart Findlow, I., Khalid, Syma, McCormick, Chris J. and Williamson, Philip T.F. Published:2015Publication:Biochimica et Biophysica Acta (BBA) - BiomembranesVolume:1848, (8)Page Range:1671-1677doi:10.1016/j.bbamem.2015.04.015