Tumbarello, David - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2014-present: Lecturer in Biomedical Sciences. Biological Sciences, University of Southampton, UK. 2010-2014: Research Associate. Cambridge Institute for Medical Research, University of Cambridge, UK. 2007-2010: Postdoctoral Fellow. Cancer Research UK, Cambridge Institute, Cambridge, UK. Academic qualifications 2006: PhD (with honours) Anatomy and Cell Biology. SUNY Upstate Medical University, Syracuse, New York, USA. 1999: BSc (cum laude) Biochemistry. Binghamton University, Binghamton, New York, USA.

研究领域

I began my scientific career evaluating the role of focal adhesion proteins in the regulation of epithelial-mesenchymal transformation and their influence on cytoskeletal rearrangement during cell migration/invasion. Following on from this, I focused on understanding the role of cell-extracellular matrix interactions and their relationship to therapeutic resistance in ovarian cancer. My more recent work has concentrated on the role of actin motor proteins and associated adaptor proteins in the regulation of different aspects of autophagy, a cellular degradation pathway. More specifically, this work has investigated how autophagy receptor specificity towards distinct cargo is coordinated and what defines their individual cellular function. Our current research focuses on understanding the cellular mechanisms and molecular machinery required for subcellular trafficking of membrane associated and cytosolic cargo via endocytosis and autophagy. These pathways are essential to regulate cell homeostasis by mediating signal regulation, receptor turnover, maintenance of energy stores, degradation of misfolded and damaged organelles, and control of pathogen invasion. In addition, we are interested in how these processes influence cell signalling, cytoskeletal reorganisation and cell morphogenesis. Understanding the requirements for receptor as well as cytosolic cargo degradation and their relationship to cellular morphogenesis is vital to understanding the molecular mechanisms of diseases such as cancer and neurodegeneration, which stem from defects in various membrane trafficking and cell signalling pathways. My lab here at the University of Southampton utilises cell, molecular, and biochemical approaches to investigate the mechanisms of vesicle trafficking along the endocytic and autophagic pathways in order to further our understanding of these complex interrelationships.

近期论文

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SPARC regulates transforming growth factor beta induced (TGFBI) extracellular matrix deposition and paclitaxel response in ovarian cancer cells - Tumbarello, David A., Andrews, Melissa R. and Brenton, James D. Published:2016Publication:PLoS ONEVolume:11, (9)Page Range:1-20doi:10.1371/journal.pone.0162698PMID:27622658 Loss of cargo binding in the human myosin VI deafness mutant (R1166X) increases actin filament binding - Arden, Susan D., Tumbarello, David A., Butt, Tariq, Kendrick-Jones, John and Buss , Folma Published:2016Publication:Biochemical JournalPage Range:1-20doi:10.1042/BCJ20160571PMID:27474411 Axonal localization of integrin receptors in the CNS is neuronal subtype and age dependent - Andrews, Melissa R., Soleman, Sara, Cheah, Menghon, Tumbarello, David A., Mason, Matthew R.J., Moloney, Elizabeth, Verhaagen, Joost, Bensadoun, Jean-Charles, Schneider, Bernard, Aebischer, Patrick and Fawcett, James W. Published:2016Publication:eNeuroVolume:3, (4)Page Range:1-14doi:10.1523/ENEURO.0029-16.2016