Gibson, Jane - University of Southampton - Discipline of Biological Sciences

个人简介

Career History 2013-present: Lecturer in Bioinformatics. Biological Sciences, University of Southampton, UK. 2012-2013: Career track award Fellow. Faculty of Medicine, University of Southampton, UK. 2008-2012: Postdoctoral research assistant. School of Medicine, University of Southampton, UK. 2002-2008: Research assistant. School of Medicine, University of Southampton, UK. Academic qualifications 2008: PhD Genetic Epidemiology and Bioinformatics. University of Southampton, UK. 2002: MSc Biosystems and Informatics. University of Liverpool, UK. 2001: BSc (Hons) Genetics. University of Leeds, UK.

研究领域

My research involves statistical genetics and bioinformatics approaches to understanding the human genome and the changes which can lead to disease. Research areas include: The determination and characterisation of linkage disequilibrium patterns and homozygous regions in disease and population studies. Studies which aim to determine genes leading to ophthalmic traits such as Age-related Macular Degeneration and Primary Open Angle Glaucoma. This involves genetic association studies and next generation sequencing (with Prof. Lotery, Faculty of Medicine). The development of in-house tools and software pipelines to enable streamlined bioinformatic analyses of next generation sequencing data. Analysis of tumour samples to determine somatic variants from exome and targeted gene sequencing approaches in cancer patients (with Dr. Sahota, and Dr. Strefford, Faculty of Medicine). Identifying genes causing Mendelian diseases by exome sequencing (with Prof. Lucassen and colleagues, Wessex Clinical Genetics Service). Detection of susceptibility genes involved in familial cancers using exome sequencing (with Prof. Lucassen and colleagues, Wessex Clinical Genetics Service).

近期论文

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New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics - Lotery, Andrew, Gibson, Jane and Cree, Angela Published:2016Publication:Human Molecular Genetics Deleterious coding variants in multi-case families with non-syndromic cleft lip and/or palate phenotypes - Pengelly, Reuben J., Arias, Liliana, Martinez, Julio, Upstill-Goddard, Rosanna, Seaby, Eleanor G., Gibson, Jane, Ennis, Sarah, Collins, Andrew and Briceno, Ignacio Published:2016Publication:Scientific ReportsVolume:6Page Range:30457 Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukemia - Parker, Helen, Rose-Zerilli, Matthew J.J., Larrayoz, Marta, Clifford, Ruth, Edelmann, Jennifer, Blakemore, Stuart, Gibson, Jane, Wang, Jun, Ljungstrom, Viktor, Wojdacz, Tomasz K., Chaplin, Tracy, Roghanian, Ali, Davis, Zadie, Parker, Anton, Tausch, Eugen, Ntoufa, Stavroula, Ramos, Sara, Robbe, Pauline, Alsolami, Reem, Steele, Andrew J., Packham, Graham, Rodriquez-Vicente, Ana E., Brown, Lee, McNicholl, Feargal, Forconi, Francesco, Pettitt, Andrew, Hillmen, Peter, Dyer, Martin, Cragg, Mark S., Chelala, Claude, Oakes, Christopher C., Rosenquist, Richard, Stamatopoulos, Kostas, Stilgenbauer, Stephan, Knight, Samantha, Schuh, Anna, Oscier, David G. and Strefford, Jonathan C. Published:2016Publication:LeukemiaPage Range:1-22 Exome sequencing in classic hairy cell leukaemia reveals widespread variation in acquired somatic mutations between individual tumours apart from the signature BRAF V(600)E lesion - Weston-Bell, Nicola J., Tapper, Will, Gibson, Jane, Bryant, Dean, Moreno, Yurany, John, Melford, Ennis, Sarah, Kluin-Nelemans, Hanneke C., Collins, Andrew R. and Sahota, Surinder S. Published:2016Publication:PLoS ONEVolume:11, (2)Page Range:1-14doi:10.1371/journal.pone.0149162PMID:26871591 Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease - Rose-Zerilli, Matthew, Gibson, Jane, Wang, Jun, Tapper, Wi, Davis, Zadie, Parker, Helen, Larrayoz, Marta, McCarthy, Helen, Walewska, Renata, Forster, Jade, Gardiner, Anne, Steele, Andrew, Chelala, Claude, Ennis, Sarah, Collins, Andrew, Oakes, Christopher, Oscier, David and Strefford, Jonathan Published:2016Publication:LeukemiaVolume:30, (6)Page Range:1301-1310doi:10.1038/leu.2016.10PMID:26847028 Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia - Mansur, Marcela B., van Delft, Frederik W., Colman, Susan M., Furness, Caroline L., Gibson, Jane, Emerenciano, Mariana, Kempski, Helena, Clappier, Emmanuelle, Cave, Hélène, Soulier, Jean, Pombo-de-Oliveira, Maria S., Greaves, Mel and Ford, Anthony M. Published:2015Publication:British Journal of HaematologyVolume:171, (4)Page Range:574-584doi:10.1111/bjh.13613PMID:26205622