Deinhardt, Katrin - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2013-present: Lecturer in Neuroscience. Biological Sciences, University of Southampton, UK. 2007-2013: Postdoctoral Research Fellow. Skirball Institute, NYU SoM, New York, USA. 2006-2007: Postdoctoral Research Fellow. Cancer Research UK, London, UK. Academic qualifications 2001-2005: PhD in Cell Biology. Cancer Research UK, UCL, London, UK. 1996-2001: Diploma in Biochemistry. FU Berlin, Berlin, Germany, UK.

研究领域

I am fascinated by the beautiful but complicated shape of individual neurons, and the complex intracellular logistics required to form, maintain and remodel these cells throughout life. Neurons extend processes that cover vast territories, which allow them to directly connect with cells distant from the soma. Our research interest is to understand how neurons integrate the different extracellular cues that they receive at distinct parts of the cell in time and space to maintain and adapt their structure and connectivity. To this end, we study the interplay of short- and long-range trafficking and signalling, and how these events ultimately converge to initiate changes in neuronal morphology and physiology. The formation and maintenance of neuronal connections requires morphological changes and is tightly coupled to activity-dependent events. In this regard, the neurotrophin BDNF provides an example of a highly regulated growth factor that triggers intracellular processes to initiate changes in cell shape. Moreover, its precursor, proBDNF, is also biologically active with largely opposing actions to those of mature BDNF, thus allowing for tightly controlled, bi-directional modulation of neuronal morphology by a single growth factor.

近期论文

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Modulation of nonsense mediated decay by rapamycin - Martinez-Nunez, Rocio, Wallace, Andrew, Coyne, Doyle, Jansson, Linnea, Rush, Miles, Ennajdaoui, Hanane, Katzman, Sol, Bailey, Joanne Louise, Deinhardt, Katrin, Sanchez-Elsner, Tilman and Sanford, Jeremy R. Published:2016Publication:Nucleic Acids ResearchPage Range:1-12doi:10.1093/nar/gkw1109PMID:27899591 Akt regulates axon wrapping and myelin sheath thickness in the PNS - Domènech-Estévez, Enric, Baloui, Hasna, Meng, Xiaosong, Zhang, Yanqing, Deinhardt, Katrin, Dupree, Jeff L., Einheber, Steven, Chrast, Roman and Salzer, James L. Published:2016Publication:Journal of NeuroscienceVolume:36, (16)Page Range:4506-4521doi:10.1523/JNEUROSCI.3521-15.2016 Stable isotope labeling by amino acids in cultured primary neurons - Zhang, Guoan, Deinhardt, Katrin and Neubert, Thomas A Published:2014Publication:Methods in Molecular BiologyVolume:1188Page Range:57-64doi:10.1007/978-1-4939-1142-4_5PMID:22238095 Proteomic approaches to dissect neuronal signaling pathways - Bowling, Heather L. and Deinhardt, Katrin Published:2014Publication:Advances in experimental medicine and biologyVolume:806Page Range:499-508doi:10.1007/978-3-319-06068-2_24PMID:24952199 Trkb signaling in pericytes is required for cardiac microvessel stabilization - Anastasia, Agustin, Deinhardt, Katrin, Wang, Shiyang, Martin, Laura, Nichol, Donna, Irmady, Krithi, Trinh, Jasmine, Parada, Luis, Rafii, Shahin, Hempstead, Barbara L. and Kermani, Pouneh Published:2014Publication:PLoS ONEVolume:9, (1)Page Range:e87406doi:10.1371/journal.pone.0087406PMID:24498100