Clarkin, Claire E - University of Southampton - Discipline of Biological Sciences

个人简介

Career History 2011-Present: Lecturer in Developmental Biology. Biological Sciences, University of Southampton, UK. 2008-2011: Diabetes Foundation/Diabetes UK Research Fellow. King’s College, London, UK. 2005-2008: Postdoctoral Research Associate (ARC): Department of Veterinary Basic Science, The Royal Veterinary College, London, UK. Academic Qualifications 2002-2005: PhD (BBSRC). The Royal Veterinary College, London, UK.

研究领域

Claires research is focussed on how blood vessels and endothelial cells interact with tissues and organs during development, adulthood and disease. More specifically, she is interested in how tissue derived factors such as vascular endothelial growth factor or transforming growth factor β can modulate endothelial cell behaviour. Examples of projects she is involved in include i) study of endothelial cell interactions in bone, during remodelling, osteoporosis and following orthopaedic surgery and ii) targeting the blood supply in of islets of langerhans to increase islet transplantation success, a current treatment for Type 1 Diabetes.

近期论文

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Are mesenchymal stem cells so bloody great after all? - Marfy-Smith, S.J. and Clarkin, Claire Published:2016Publication:Stem Cells Translational Medicine doi:10.5966/sctm.2016-0026 Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function - Clarkin, Claire, Mahmoud, Marwa, Liu, Bo, Sobamowo, Emmanuel O., King, Aileen, Arthur, Helen, Jones, Peter M. and Wheeler-Jones, Caroline P. Published:2016Publication:BMC Research NotesVolume:9, (1)doi:10.1186/s13104-016-2142-z Editorial. Achieving tissue specific levels of angiogenesis: Not(ch) a big deal! - Clarkin, Claire E. Published:2015Publication:Annals of Translational MedicinePage Range:1-3doi:10.3978/j.issn.2305-5839.2015.07.05PMID:26417574 Local origins impart conserved bone type-related differences in human osteoblast behaviour - Shah, M., Gburcik, V., Reilly, P., Sankey, R.A., Emery, R.J., Clarkin, C.E. and Pitsillides, A.A. Published:2015Publication:European Cells & MaterialsVolume:4, (29)Page Range:155-176PMID:25738584 ALK5 inhibition maintains islet endothelial cell survival but does not enhance islet graft revascularisation or function. - King, A.J.F., Clarkin, C.E., Austin, A.L.F., Ajram, L., Dhunna, J.K., Jamil, M.O., Ditta, S.I., Ibrahim, S., Raza, Z. and Jones, P.M. Published:2015Publication:Hormone and Metabolic ResearchVolume:47, (1)Page Range:78-83doi:10.1055/s-0034-1395567PMID:25429440