Andrews, Melissa R - University of Southampton - Discipline of Biological Sciences

个人简介

Career History 2017-present: Lecturer in Systems Physiology, Biological Sciences, University of Southampton, Southampton, UK. 2012-2016: Lecturer in Anatomy, University of St Andrews, School of Medicine, St Andrews, UK. 2006-2012: Postdoctoral Research Associate, University of Cambridge, Centre for Brain Repair, Cambridge, UK. Academic qualifications 2000-2006: PhD (with honours) in Anatomy and Cell Biology. State University of New York Upstate Medical University, Syracuse, NY, USA. 1996-2000: BSc in Bioengineering. University of Illinois at Urbana-Champaign, Urbana, IL, USA.

研究领域

My research focus is aimed at enhancing repair of the acutely or chronically injured brain and spinal cord as well as investigating why certain parts of the nervous system can regenerate while others do not. My work involves targeting the intrinsic inability of the CNS to regenerate using various approaches to reintroduce necessary proteins that are missing in the adult and injured nervous systems, including utilising gene therapy and cell-derived vesicles. In addition, I am interested in incorporating cellular therapies to promote neuroprotection and regrowth in the damaged or degenerated nervous system.

近期论文

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Targeting cell surface receptors for axon regeneration in the central nervous system - Andrews, Melissa R. and Cheah, Menghon Published:2017Publication:Neural Regeneration ResearchVolume:11, (12)Page Range:1884-1887doi:10.4103/1673-5374.197079 SPARC regulates transforming growth factor beta induced (TGFBI) extracellular matrix deposition and paclitaxel response in ovarian cancer cells - Tumbarello, David A., Andrews, Melissa R. and Brenton, James D. Published:2016Publication:PLoS ONEVolume:11, (9)Page Range:1-20doi:10.1371/journal.pone.0162698PMID:27622658 Axonal localization of integrin receptors in the CNS is neuronal subtype and age dependent - Andrews, Melissa R., Soleman, Sara, Cheah, Menghon, Tumbarello, David A., Mason, Matthew R.J., Moloney, Elizabeth, Verhaagen, Joost, Bensadoun, Jean-Charles, Schneider, Bernard, Aebischer, Patrick and Fawcett, James W. Published:2016Publication:eNeuroVolume:3, (4)Page Range:1-14doi:10.1523/ENEURO.0029-16.2016 Expression of an activated integrin promotes long-distance sensory axon regeneration in the spinal cord - Cheah, M., Andrews, M.R, Chew, D.J., Moloney, E B., Verhaagen, J., Fassler, R. and Fawcett, J.W. Published:2016Publication:Journal of NeuroscienceVolume:36, (27)Page Range:7283-7297doi:10.1523/JNEUROSCI.0901-16.2016PMID:27383601 Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in cns axons - Kappagantula, S., Andrews, M.R., Cheah, M., Abad-Rodriguez, J., Dotti, C.G. and Fawcett, J.W. Published:2014Publication:Journal of NeuroscienceVolume:34, (7)Page Range:2477-2492doi:10.1523/JNEUROSCI.4432-13.2014