Smyth, Neil - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2014-present: Reader in Development and Cell Biology. University of Southampton, UK. 2007-2014: Lecturer in Development and Cell Biology. University of Southampton, UK. Research Fellow. Max Planck Institute of Neurobiology, Martinsried, Germany. Research Fellow. Max Planck Institute of Neurobiology, Martinsried, Germany. Academic qualifications PhD. University of Liverpool, UK. BSc. University of Liverpool, UK.

研究领域

My research has focused upon the structure and function of the extracellular matrix, in particular the actions and importance of a specialised matrix, the basement membrane. Basement membranes are crucial in development and have been shown highly significant in many developmental processes, I have studied the roles of its constituent proteins, their receptors and modulator proteins. With an emphasis on structure-function relationships I have used in vivo and in vitro genetic approaches to determine protein function, following initial biochemical findings and using biochemical, biophysical, cell-biological and developmental biological assays I try to determine the in vivo significance of the basement membrane and its constituent proteins in physiological and pathological situations. More recently I have studied the developmental and pathological roles of transglutaminases, crosslinking enzymes which have been shown to play a role in the stabilisation of extracellular matrices. 1. The roles of the basement membrane in development 2. Transglutaminases role in the formation of biological barriers

近期论文

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Deposition of amyloid-beta in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy - Keable, Abby, Fenna, Kate, Yuen, Ho Ming, Johnston, David A., Smyth, Neil R., Smith, Colin, Al-Shahi Salman, Rustam, Samarasekera, Neshika, Nicoll, James A.R., Attems, Johannes, Kalaria, Rajesh N., Weller, Roy O. and Carare, Roxana O. Published:2015Publication:Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseVolume:1862, (5)Page Range:1037-1046doi:10.1016/j.bbadis.2015.08.024PMID:26327684 Antagonistic human FcyRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo - Roghanian, A., Teige, I., Martensson, L., Cox, K.L., Kovacek, M., Ljungars, A., Mattson, J., Sundberg, A., Vaughan, A.T., Shah, V., Smyth, N.R., Sheth, B., Chan, H.T.C., Li, Z.-C., Williams, E.L., Manfredi, G., Oldham, R.J., Mockridge, C.I., James, S.A., Dahal, L.N., Hussain, K., Nilsson, B., Verbeek, J.S., Juliusson, G., Hansson, M., Jerkeman, M., Johnson, P.W.M., Davies, A., Beers, S.A., Glennie, M.J., Frendeus, B. and Cragg, M.S. Published:2015Publication:Cancer CellVolume:27, (4)Page Range:473-488doi:10.1016/j.ccell.2015.03.005PMID:25873171 Antagonistic Human Fc?RIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. - Roghanian, Ali, Teige, Ingrid, Mårtensson, Linda, Cox, Kerry L., Kovacek, Mathilda, Ljungars, Anne, Mattson, Jenny, Sundberg, Annika, Vaughan, Andrew T., Shah, Vallari, Smyth, Neil R., Sheth, Bhavwanti, Chan, H.T. Claude, Li, Zhan-Chun, Williams, Emily L., Manfredi, Giusi, Oldham, Robert J., Mockridge, C. Ian, James, Sonya A., Dahal, Lekh N., Hussain, Khiyam, Nilsson, Björn, Verbeek, J. Sjef, Juliusson, Gunnar, Hansson, Markus, Jerkeman, Mats, Johnson, Peter W.M., Davies, Andrew, Beers, Stephen A., Glennie, Martin J., Frendéus, Björn and Cragg, Mark S. Published:2015Publication:Cancer CellVolume:27, (4)Page Range:473-488doi:10.1016/j.ccell.2015.03.005PMID:25873171