Barton, C Howard - University of Southampton - Discipline of Biological Sciences

个人简介

Career history Reader in Biochemistry & Molecular Biology. University of Southampton, UK. Research Fellow. Institute of Neurology, University of London, UK. Guy's Hospital, University of London, UK. London School of Hygiene & Tropical Medicine, University of London, UK. Addenbrooke's Hospital, University of Cambridge, UK. Academic qualifications PhD in Biochemistry. University of Sheffield, UK. BSc in Chemistry/Biochemistry (Jt.Hons). University of Nottingham, UK.

研究领域

Nramp1 controls proliferation of intracellular pathogens and encodes an intracellular divalent cation (including ferrous iron) transporter. Its role in iron transport within the macrophage, particularly erythrophagocytosis, and its regulation by haem at the level of gene transcription are being examined. Viral proteins effect macrophage function. The roles of HIV-1 Tat and Nef are being examined using cell transfectants.

近期论文

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Catalytic and non-catalytic functions of human IIA phospholipase A2 - Birts, Charles N., Barton, C. Howard and Wilton, David C. Published:2010Publication:Trends in Biochemical SciencesVolume:35, (1)Page Range:28-35doi:10.1016/j.tibs.2009.08.003 Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition - Nairz, Manfred, Fritsche , Gernot, Crouch, Marie-Laure V., Barton, Howard C., Fang, Ferric C. and Weiss, Günter Published:2009Publication:Cellular MicrobiologyVolume:11, (9)Page Range:1365-1381doi:10.1111/j.1462-5822.2009.01337.x Nramp1-functionality increases iNOS expression via repression of IL-10 formation - Fritsche, Gernot, Nairz, Manfred , Werner, Ernst R. , Barton, Howard C. and Weiss, Gunter Published:2008Publication:European Journal of ImmunologyVolume:38, (11)Page Range:3060-3067doi:10.1002/eji.200838449 A catalytically independent physiological function for human acute phase protein group IIA phospholipase A2: cellular uptake facilitates cell debris removal - Birts, Charles N., Barton, C. Howard and Wilton, David C. Published:2008Publication:Journal of Biological ChemistryVolume:283, (8)Page Range:5034-5045doi:10.1074/jbc.M708844200 Immunolo calisation of the D-melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous - Folwell, James L., Barton, C. Howard and Shepherd, DavidPublished:2006Publication:Journal of Experimental BiologyVolume:209, (10)Page Range:1988-1995doi:10.1242/jeb.02193