Wijnen, Herman - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2014-Present: Associate Professor in Biological Sciences. University of Southampton, UK. 2012-2014: Senior Lecturer in Biological Sciences. University of Southampton, UK. 2004-2012: Assistant Professor Biology. The University of Virginia, USA. 2000-2004: Postdoc Circadian Biology. The Rockefeller University, USA. Academic qualifications 2000: PhD Genetics. Stony Brook University/Cold Spring Harbor Laboratory, USA. 1993: Drs MSc Biomedical Sciences. Leiden University, The Netherlands.

研究领域

Why do we sleep at night? What causes jet lag? How can molecules measure time? To answer these and related questions we study biological systems for daily time keeping that are known as circadian clocks. Circadian clocks allow organisms to organize their bodily functions in a daily schedule and keep their internal rhythms in sync with environmental rhythms of light and temperature. We would like to know what genes and molecules are involved in the function of circadian clocks and how they function together to measure time and coordinate biological rhythms. For our research we use the fruit fly Drosophila melanogaster as an experimental model. This model system is not only convenient to use, but it also offers powerful tools for conducting genetic, molecular, and behavioural studies. Moreover, as it turns out, the molecular mechanisms of the clock in Drosophila are very similar to those in mammals and we have already learned a lot about the internal clocks of humans by studying flies

近期论文

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Temperature-dependent resetting of the molecular circadian oscillator in Drosophila - Goda, Tadahiro, Sharp, Brandi and Wijnen, Herman Published:2014Publication:Proceedings of the Royal Society B: Biological SciencesVolume:281, (1793)doi:10.1098/rspb.2014.1714PMID:25165772 Adult Circadian behavior in Drosophila requires developmental expression of cycle, but not period - Goda, Tadahiro, Mirowska, Karolina, Currie, Jake, Kim, Min-Ho, Rao, Neethi Varadaraja, Bonilla, Gloribel and Wijnen, Herman Published:2011Publication:PLoS GeneticsVolume:7, (7)Page Range:e1002167-[19pp]doi:10.1371/journal.pgen.1002167PMID:21750685 Fluorescence/luminescence circadian imaging of complex tissues at single-cell resolution - Sellix, Michael T., Currie, Jake, Menaker, Michael and Wijnen, Herman Published:2010Publication:Journal of Biological RhythmsVolume:25, (3)Page Range:228-232doi:10.1177/0748730410368016PMID:20484694 Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets - Wang, Hongyin, Carey, Lucas B., Cai, Ying, Wijnen, Herman and Futcher, Bruce Published:2009Publication:PLoS BiologyVolume:7, (9)Page Range:e1000189-[14pp]doi:10.1371/journal.pbio.1000189PMID:19823669 Selective entrainment of the Drosophila circadian clock to daily gradients in environmental temperature - Currie, Jake, Goda, Tadahiro and Wijnen, Herman Published:2009Publication:BMC BiologyVolume:7, (49)Page Range:1-19doi:10.1186/1741-7007-7-49PMID:19671128