Ewing, Rob M - University of Southampton - Discipline of Biological Sciences

个人简介

Career History 2014-Present: Associate Professor in Proteomics and Systems Biology. University of Southampton, UK. 2013-2014: Lecturer in Proteomics and Systems Biology. University of Southampton, UK. Assistant Professor. School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Team Leader, Bioinformatics. MDS Proteomics, Toronto, Canada. Senior Bioinformatics Scientist. Incyte Genomics, California, USA. Postdoctoral Fellow. Carnegie Institute, Stanford University, California, USA. Postdoctoral Fellow. Information Genetique et Structurale, CNRS, Marseille, France. Academic qualifications Bsc (Hons) Applied Biology. University of Bath, UK. DPhil Molecular Genetics, Dept. Plant Sciences, University of Oxford, UK.

研究领域

Proteins are the 'molecular machines' of the cell, and perform many of the essential functions in biological systems. In many cases, however, proteins do not act alone but rather physically interact with other proteins and other types of biomolecules to carry out their functions. These sets of interacting proteins, termed 'protein complexes' are themselves organized into larger networks of proteins that function in a coordinated manner. Understanding which proteins interact with which, and where and when these interactions occur, is therefore essential to understanding protein function. The broad goal of our research is to understand these protein interaction networks, ultimately defining a 'systems-wide' protein interaction map that will both provide insights into the function of individual proteins as well as the organization of proteins within the cell.

近期论文

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Noise-processing by signaling networks - Kontogeorgaki, Styliani, Sanchez Garcia, Ruben, Zygalakis, Konstantinos, Ewing, Robert and Macarthur, Benjamin Published:2016Publication:Author's OriginalPage Range:1-10 Single-cell pluripotency regulatory networks - Stumpf, Patrick, Ewing, Rob and Macarthur, Ben D. Published:2016Publication:PROTEOMICSVolume:16, (17)Page Range:2303-2312doi:10.1002/pmic.201500528 Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta - Rast-Somssich, Madlen I., Broholm, Suvi, Jenkins, Huw, Canales, Claudia, Vlad, Daniela, Kwantes, Michiel, Bilsborough, Gemma, Dello Ioio, Raffaele, Ewing, Rob M., Laufs, Patrick, Huijser, Peter, Ohno, Carolyn, Heisler, Marcus G., Hay, Angela and Tsiantis, Miltos Published:2015Publication:Genes & DevelopmentVolume:29, (22)Page Range:2391-2404doi:10.1101/gad.269050.115PMID:26588991 Proteomic and bioinformatics profile of paired human alveolar macrophages and peripheral blood monocytes - Tomechko, Sara E., Lundberg, Kathleen C., Jarvela, Jessica, Bebek, Gurkan, Chesnokov, Nicole G., Schlatzer, Daniela, Ewing, Rob M., Boom, W. Henry, Chance, Mark R. and Silver, Richard F. Published:2015Publication:PROTEOMICSVolume:15, (22)Page Range:3797-3805doi:10.1002/pmic.201400496PMID:26389541 How do oncoprotein mutations rewire protein–protein interaction networks? - Bowler, Emily, Wang, Zhenghe and Ewing, Rob Published:2015Publication:Expert Review of ProteomicsVolume:12, (5)Page Range:449-455doi:10.1586/14789450.2015.1084875