Teeling, Jessica L. - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2016-present: Professor in Experimental Neuroimmunology. University of Southampton, UK. 2014-2016 Associate Professor in Immunology. University of Southampton, UK. 2008-2014: Lecturer. University of Southampton, UK. 2004-2008: Postdoctoral Research Fellow. CNS inflammation group, Biological Sciences, University of Southampton, UK. 2004-2008: Postdoctoral Research Fellow. Cancer Sciences, Medicine, University Southampton, UK. 2001-2004: Research Scientist. Genmab, The Netherlands. Academic qualifications 2001: PhD degree. University of Amsterdam, The Netherlands. 1996: Doctoral degree. University of Amsterdam, The Netherlands.

研究领域

My research focuses on understanding the immune regulatory pathways in the healthy, diseased and ageing central nervous system (CNS). We study the effect of antibody mediated inflammation in the CNS, and how these responses may contribute to the pathogenesis of neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease, age related macular degeneration and systemic lupus erythematosis. We are particularly interested in the role of Fcgamma receptors and microglial activation. We also study the effect of systemic inflammation on the central nervous system, using real bacterial and viral infection models. We are interested in the cellular and molecular mechanisms underlying the physiological, metabolic and behavioural changes during systemic infection and we investigate the immunological changes in the CNS that occur during ageing or age-related neurological diseases. Using novel models for AMD, we will investigate the functional role of antibodies in disease onset and progression. This MRC funded CASE studentship aims to understanding the role of FcγR in immunotherapy for neurodegenerative diseases. This work is in collaboration with Lundbeck.

近期论文

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Periodontitis and cognitive decline in Alzheimer's disease. - Ide, Mark, Harris, Marina, Stevens, Annette, Sussams, Rebecca, Hopkins, Viv, Culliford, David, Fuller, James, Ibbett, Paul, Raybould, Rachel, Thomas, Rhodri, Puenter, Ursula, Teeling, Jessica, Perry, V. Hugh and Holmes, Clive Published:2016Publication:PLoS ONEVolume:11, (3)Page Range:1-9doi:10.1371/journal.pone.0151081PMID:26963387 Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies - Fuller, J.P., Stavenhagen, J., Christensen, S., Kartborg, F., Glennie, M. and Teeling, J. Published:2015Publication:Acta NeuropathologicaVolume:130, (5)Page Range:699-711doi:10.1007/s00401-015-1484-2PMID:26433971 Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial. - Butchart, Joseph, Brook, Laura, Hopkins, Vivienne, Teeling, Jessica, Puntener, Ursula, Culliford, David, Sharples, Richard, Sharif, Saif, McFarlane, Brady, Raybould, Rachel, Thomas, Rhodri, Passmore, Peter, Perry, V. Hugh and Holmes, Clive Published:2015Publication:NeurologyVolume:84, (21)Page Range:2161-2168doi:10.1212/WNL.0000000000001617 PMID:25934853 New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease - Fuller, James P., Stavenhagen, Jeffrey B. and Teeling, Jessica L. Published:2014Publication:Frontiers in NeuroscienceVolume:8doi:10.3389/fnins.2014.00235 Fcy receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration - Murinello, S., Mullins, R.F., Lotery, A.J., Perry, V.H. and Teeling, Jessica L. Published:2014Publication:Investigative Ophthalmology & Visual ScienceVolume:55, (1)Page Range:247-258doi:10.1167/iovs.13-11821PMID:24334446