Smith, Peter J S - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2011-present: Director, Institute for Life Sciences (IfLS). University of Southampton, UK. 2011-present: Professor of Life Sciences. Faculty of Natural and Environmental Sciences, Univ. of Southampton, UK. 2013-present: Visiting Fellow, Marine Biological Association, Plymouth, UK. 2008-2011: Director, Cellular Dynamics Program, Marine Biological Laboratory (MBL), USA. 2008-2011: Adjunct Professor of Engineering (Research), Brown University, RI. 2002-2008: Director, Molecular Physiology Program, MBL, USA. 1999-2011: Senior Scientist, MBL, USA. 1996-2011: Director and Principal Investigator, NIH BioCurrents Research Center, MBL. 1994-1996: Director and PI, NIH National Vibrating Probe Facility, MBL. 1992-1993: Co-Director, NIH Nat’l Vibrating Probe Facility, MBL, USA. (With L. F. Jaffe). 1992-1999: Associate Scientist, MBL, USA. 1990-1991: Senior Scientific Officer and Lab. Leader, AFRC Laboratory of Molecular Signalling, Dept. of Zoology, University of Cambridge and the Babraham Research Institute, UK. 1987-1990: Higher Scientific Officer, AFRC Unit of Insect Neurophysiology and Pharmacology, Dept. of Zoology, University of Cambridge, UK. 1986-1991: Fellow and Director of Studies in Natural Sciences, Sidney Sussex College, Cambridge, UK. 1985-1987: Leverhulme Research Fellow, University of Cambridge, Dept. of Zoology, Cambridge, UK. 1982-1984: Research Associate, University of Cambridge, Dept. of Zoology, Cambridge, UK (With J. E. Treherne). 1979-1982: Research Associate, University of Manchester, UK. (With D.M. Guthrie). 1991: MA Neurosciences, University of Cambridge, UK. 1976-1979: PhD Comparative Cardiovascular Physiology, University of Aberdeen, Scotland. 1972-1976: BSc Zoology (1st Class). University of Aberdeen, UK.

研究领域

1. Cellular metabolism, oxygen consumption and the mitochondrion Using both molecular and electrochemical techniques this research examines the dynamics of mitochondrial function in normal and diseased cells. I am also interested in further developing micron proportioned amperometric sensors to map oxygen profiles around single identified cells. With postoctoral researcher Dr John Findlay. External collaborators, Dr Kambiz Alavian (Imperial) and Prof. E. Jonas (Yale) Doctoral Candidates 2016 Maria Strickland: Cellular metabolism and regulation of mitochondrial efficiency - healthy ageing across the life course. With primary supervisor Sylvia Pender and David Johnson (UoS: Medicine) and Anis Larbi (A*STAR) 2015 Eleni Georgiades: Characterisation of a new mitochondrial potassium channel, K2P15.1. BBSRC With Maurits De Planque (UoS: Electronic and Computing Science) and Ita O’Kelly (Enterprise). 2. Developing new super-oscillatory technology for unlabelled super-resolution cellular imaging In collaboration with researchers in the Optoelectronics Research Centre I’m working on developing a novel method for super-resolution imaging of unlabelled living cells. The technique fuses the principles of the super-oscillating lens with an advanced form of polarised microscopy. With postodctoral researcher Dr Edward Rogers And investigators Prof Nikolay Zheludev (ORC), Prof John Chad (FNES) and Dr Tracey Newman (Medicine). External advisory Dr Rudolf Oldenbourg, MBL and Univ. of Chicago. Southampton Enterprise Fund 2013 – 2016: PI £480K 3. Optical tools for ion measurement Collaborating with chemists Richard and Linda Brown as well as Phil Bartlett we are designing activated nanoscale substrates with tethered sensors to return ion activity with nanodimension spatial information. The goal is to generate cell compatible surfaces reporting, in real time, the changes in boundary layer ion activity. We’re currently targetting hydrogen and potassium ions. Doctoral Candidate 2014 Victor Lethuillier, Chemistry: Imaging substrates for monitoring the diffusive boundary layer of living cells. With Phil Bartlett, Richard Brown and Linda Brown (UoS: Chemistry). 4. Microenvironment regulaton in phytoplankton Collaborating with Prof Colin Brownlee of OES and the MBA Plymouth, I contribute expertise to the critical mechanistic understanding of membrane transport, cellular regulation and key physiological processes at the single cell level along with information on the microenvironment that surrounds cells. We’re studying transport processes in phytoplankton, including the coccolithophores and their calcium carbonate deposition mechanism.

近期论文

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C60fullerene localization and membrane interactions in RAW 264.7 immortalized mouse macrophages - Russ, K.A., Elvati, P., Parsonage, T.L., Dews, A., Jarvis, J.A., Ray, M., Schneider, B., Smith, P.J.S., Williamson, P.T.F., Violi, A. and Philbert, M.A. Published:2016Publication:NanoscaleVolume:8, (7)Page Range:4134-4144doi:10.1039/c5nr07003a Probing the epigenetic regulation of HIF-1? transcription in developing tissue - Mistry, Ishna N., Smith, Peter J.S., Wilson, David I. and Tavassoli, Ali Published:2015Publication:Molecular BioSystemsPage Range:1-6doi:10.1039/C5MB00281HPMID:26066786 The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole - Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Signore, A.P., Smith, P.J.S., Gribkoff, V.K. and Jonas, E.A. Published:2015Publication:Molecular PharmacologyVolume:87, (1)Page Range:1-8doi:10.1124/mol.114.095661PMID:25332381 Paper-based colorimetric enzyme linked immunosorbent assay fabricated by laser induced forward transfer - Katis, Ioannis N., Holloway, Judith A., Madsen, Jens, Faust, Saul N., Garbis, Spiros D., Smith, Peter J.S., Voegeli, David, Bader, Dan L., Eason, Robert W. and Sones, Collin L. Published:2014Publication:BiomicrofluidicsVolume:8, (3)Page Range:1-10doi:10.1063/1.4878696PMID:24926392 Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease - Brodsky, Alexander S., Fischer, Andrew, Miller, Daniel H., Vang, Souriya, MacLaughlan, Shannon, Wu, Hsin-Tu, Yu, Jovian, Steinhoff, Margaret, Collins, Colin, Smith, Peter J.S., Raphael, Benjamin J. and Brard, Laurent Published:2014Publication:PLoS ONEVolume:9, (4)Page Range:e94476doi:10.1371/journal.pone.0094476