Perry, V Hugh - University of Southampton - Discipline of Biological Sciences

个人简介

Career history Chair Neuroscience and Mental Health Board. MRC, UK. 2011-present: Visiting Professor in the College of Medicine & Veterinary Medicine. University of Edinburgh, UK. 1998-present: Professor of Experimental Neuropathology. University of Southampton, UK. 1996-1998: Professor of Experimental Neuropathology. University of Oxford, UK. Locke Royal Society Research Fellow,UK. Wellcome Trust Senior Research Fellow, UK. 1977-1996: Research Fellow, University of Oxford, UK.

研究领域

Inflammation in the CNS and its contribution to Neurological Disease The inflammatory response evolved to protect organisms against injury and infection. Following an injury or infection a complex cascade of events leads to the delivery of blood-borne leucocytes to sites of injury to kill potential pathogens and promote tissue repair. However, the powerful inflammatory response has the capacity to cause damage to normal tissue and dysregulation of the innate or acquired immune response is involved in different pathologies. It has long been known that Multiple Sclerosis is an inflammatory disease of the brain but it is now recognized that inflammation may contribute to diseases such as stroke, traumatic brain injury, HIV-related dementia, Alzheimer's disease and prion disease. The recognition of an inflammatory component in the pathology of these different diseases has come from the development of new techniques and reagents for the study of inflammation biology in brain pathology. It is now known that the resident macrophages of the central nervous system (CNS), the microglia, may exist in many different states of activation and contribute to the outcome of neurological disease in diverse ways. The goal of my research group the CNS Inflammation Group is to discover how inflammation contributes to the outcome of neurological disease. This information may help in the development of therapies to treat acute and chronic neurodegenerative conditions, which at present are largely untreated. Inflammation biology in the brain is a complex subject and requires expertise in many different areas. We have collaborations with academic laboratories across the University of Southampton, the UK, as well as with laboratories across Europe.

近期论文

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Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain - Askew, Katharine, Li, Kaizhen, Olmos Alonso, Adrian, Garcia-Moreno , Fernando, Liang, Yajie, Richardson, Philippa, Tipton, Thomas, Chapman, Mark, Riecken, Kristoffer, Beccari, Sol, Sierra, Amanda, Molnar, Zoltan, Cragg, Mark S., Garaschuk, Olga, Perry, Hugh and Gomez-Nicola, Diego Published:2017Publication:Cell ReportsVolume:18, (2)Page Range:391-405doi:10.1016/j.celrep.2016.12.041 Distribution of misfolded prion protein seeding activity alone does not predict regions of neurodegeneration. - Alibhai, James, Blanco, Richard A., Barria, Pedro Piccardo, Caughey, Byron and Perry, Hugh Published:2016Publication:PLoS BiologyPage Range:1-34 CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves - Martinez-Muriana, Anna, Mancuso, Renzo, Francos-Quijorna, Isaac, Olmos-Alonso, Adrian, Osta, Rosario, Perry, Hugh, Navarro, Xavier, Gomez-Nicola, Diego and Lopez-Vales, Ruben Published:2016Publication:Scientific ReportsVolume:6, (25663)Page Range:1-13doi:10.1038/srep25663PMID:27174644 Periodontitis and cognitive decline in Alzheimer's disease. - Ide, Mark, Harris, Marina, Stevens, Annette, Sussams, Rebecca, Hopkins, Viv, Culliford, David, Fuller, James, Ibbett, Paul, Raybould, Rachel, Thomas, Rhodri, Puenter, Ursula, Teeling, Jessica, Perry, V. Hugh and Holmes, Clive Published:2016Publication:PLoS ONEVolume:11, (3)Page Range:1-9doi:10.1371/journal.pone.0151081PMID:26963387 The use of human neurons for novel drug discovery in dementia research - Vargas-Caballero, Mariana, Willaime-Morawek, Sandrine, Gomez-Nicola, Diego, Perry, V. Hugh, Bulters, Diedrik and Mudher, Amrit Published:2016Publication:Expert Opinion on Drug DiscoveryPage Range:1-35doi:10.1517/17460441.2016.1154528PMID:26878555