Lillycrop, Karen A - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 2014-present: Professor of Epigenetics, Biological Sciences, University of Southampton 2012- 2014: Reader in Epigenetics, Biological Sciences, University of Southampton 2007-2012: Senior Lecturer in Epigenetics, Biological Sciences, University of Southampton 1995-2007: Lecturer, Department of Biochemistry, University of Southampton 1987-1992: Postdoctoral Research Fellow, Department of Molecular Pathology, University College, London 1992-1995: Postdoctoral Research Fellow, Department of Molecular Pathology, University College, London Academic qualifications 1981-1984: Chemistry and Biochemistry First Class BSc (Joint Hons) Imperial College London 1984-1987: Biochemistry, PhD, University of Leicester

研究领域

EpiGen Global Research Consortium: Dr Lillycrop is a founder member of the Epigen consortium , an international consortium, investigating the role of epigenetic processes in the developmental origins of disease . Epigen members include the University of Southampton the Medical Research Council, AgResearch New Zealand, the University of Auckland, and the Singapore Institute of Clinical Sciences. Epigenetic mechanisms and the developmental origins of health and disease The incidence of non-communicable diseases (NCD) such as diabetes, cardiovascular disease and the metabolic syndrome has risen sharply over the last 20 years and has now reached epidemic proportions. Genome wide association studies have shown that fixed genomic variations can only explain a fraction of the variation in NCD risk within a population. There is however increasing evidence that the environment particularly early life environment can influence our future disease risk. In humans a poor intrauterine environment has been associated with an increased risk of a range of non communicable diseases in later life. The mechanism by which early life environment can influence future disease risk is beginning to be understood and may involve epigenetic processes. Epigenetic processes are defined as processes that induce stable changes in gene activity without a change in gene sequence. The major epigenetic processes being DNA methylation, histone modification and miRNAs. There is now growing evidence that a range of environmental factors including diet can alter the epigenome. The epigenome is most susceptible to change during the prenatal and neonatal periods. The understanding of the mechanism by which early life environment can alter the epigenome leading to long term changes in disease risk is now critical both for the identification of individuals at increased risk and the development of intervention strategies to combat the rapid rise in NCDs. Identification of epigenetic biomarkers for adult disease (EpiGen Consortium). This academic consortium is comprised of researchers from University of Southampton, Liggins Institute, University of Auckland, AgResearch New Zealand, the Medical Research Council and the Singapore Institute of Clinical Sciences. Working together with the MRC Lifecourse Epidemiology Unit and the Southampton NHIR Biomedical Research Unit in Nutrition, Diet and Lifestyle the aim of EpiGen (led in the UK by Professor Mark Hanson, Professor Keith Godfrey, Professor Cyrus Cooper, Dr Graham Burdge and Dr Karen Lillycrop) is to translate basic research in epigenetics into biomarkers and interventions to reduce the burden of non-communicable disease. In the UK, this translational research is centred around the Southampton Women's Survey.

近期论文

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DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years - Murray, Robert, Bryant, Jennifer, Titcombe, Philip, Barton, Sheila, Inskip, Hazel, Harvey, Nicholas, Cooper, Cyrus, Lillycrop, Karen, Hanson, Mark and Godfrey, Keith Published:2016Publication:Clinical EpigeneticsVolume:8, (90)Page Range:1-6doi:10.1186/s13148-016-0259-5PMID:27594927 Association between perinatal methylation of the neuronal differentiation regular HES1 and later childhood neurocognitive function and behaviour - Lillycrop, Karen A., Costello, Paula M, Teh, Ai Ling, Murray, Robert J., Clarke-Harris, Rebecca, Barton, Sheila J., Garratt, Emma S., Ngo, Sherry, Sheppard, Alan M., Wong, Johnny, Dogra, Shaillay, Burdge, Graham C., Cooper, Cyrus, Inskip, Hazel M., Gale, Catharine R., Gluckman, Peter D., Harvey, Nicholas C., Chong, Yap-Seng, Yap, Fabian, Meaney, Michael J., Rifkin-Grabot, Anne, Holbrook, Joanna and Godfrey, Keith M. Published:2016Publication:International Journal of EpidemiologyPage Range:1-48 Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study - Price, R. Jordan, Lillycrop, Karen A. and Burdge, Graham C. Published:2016Publication:Journal of Nutritional ScienceVolume:5, (e17)Page Range:1-8doi:10.1017/jns.2016.8 Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH - Bruce, K.D., Szczepankiewicz, D, Sihota, K.K., Ravindraanandan, M., Thomas, H., Lillycrop, K.A., Burdge, G.C., Hanson, M.A., Byrne, C.D. and Cagampang, F.R. Published:2016Publication:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsVolume:1861, (7)Page Range:584-593PMID:27040510 Altered cellular redox status, sirtuin abundance and 1 clock gene expression in a mouse model of developmentally primed NASH - Bruce, Kimberley, Szczepankiewicz, Dawid, Sihota, Kiran K., Ravindraanandan, Manoj, Thomas, Hugh, Lillycrop, Karen A., Burdge, Graham C., Hanson, Mark A., Byrne, Christopher D. and Cagampang, Felino R. Published:2016Publication:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsPage Range:1-29doi:10.1016/j.bbalip.2016.03.026PMID:27040510