Holden-Dye, Lindy - University of Southampton - Discipline of Biological Sciences

个人简介

Professor Lindy Holden-Dye holds a personal Chair in Neuroscience within Biological Sciences at the University of Southampton. Her interests focus on fundamental processes of neuronal communication and she has established research expertise in invertebrate preparations. Much of her work resonates with issues concerning mental health such as addiction and neurodegeneration. Her expertise in invertebrate neuroscience, and in particular nematode neural systems and the model genetic organism Caenorhabditis elegans positions her well to participate in drug discovery and mode of action programmes for novel antiparasitics. For the last two decades she has has collaborated with industry to improve prospects for parasitic nematode control The experimental approaches deployed in her research group encompass genetics through to whole animal physiology and incorporate novel methods for tracking animal behaviour and signal processing.

研究领域

I am interested in the fundamental processes of neuronal communication and have established research expertise in simple invertebrate preparations. Much of my work now resonates with issues concerning mental health such as addiction and neurodegeneration. My expertise in invertebrate neuroscience, and in particular nematode neural systems and C. elegans, positions me well to participate in drug discovery and mode of action programmes for novel antiparasitics. For the last decade I have collaborated with industry to improve prospects for parasitic nematode control. The experimental approaches deployed in my research encompass genetics through to whole animal physiology and incorporate novel methods for tracking animal behaviour and signal processing.

近期论文

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Chemical activation of a food deprivation signal extends lifespan - Lucanic, Mark, Garrett, Theo, Yu, Ivan, Calahorro Nunez, Fernando, Asadi Shahmirzadi, Azar, Miller, Aaron, Gill, Matthew S., Hughes, Robert E., Holden-Dye, Linda and Lithgow, Gordon J. Published:2016Publication:Aging CellVolume:15, (5)Page Range:832-841doi:10.1111/acel.12492 Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans - Dillon, James, Holden-Dye, Linda, O'connor, Vincent and Hopper, Neil Published:2016Publication:Invertebrate NeuroscienceVolume:16, (4)Page Range:1-10doi:10.1007/s10158-016-0187-2 Report on the 13th symposium on invertebrate neurobiology held 26–30 August 2015 at the Balaton Limnological Institute, MTA Centre for ecological research of the Hungarian Academy of Sciences, Tihany, Hungary - Crisford, Anna, Holden-Dye, Linda and Walker, Robert J. Published:2016Publication:Invertebrate NeuroscienceVolume:16, (2)doi:10.1007/s10158-016-0186-3 Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability - Dalliere, N., Bhatla, N., Luedtke, Z., Ma, D.K., Woolman, J., Walker, R., Holden-Dye, L. and O'Connor, V. Published:2015Publication:The FASEB JournalVolume:30, (2)Page Range:836-848doi:10.1096/fj.15-279257PMID:26514165 The cyclooctadepsipeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits - Crisford, A., Ebbinghaus-Kintscher, U., Schoenhense, E., Harder, A., O'Kelly, I., Ndukwe, K., O'Connor, V., Walker, R., Welz, C. and Holden-dye, L. Published:2015Publication:PLoS Neglected Tropical DiseasesPage Range:1-20doi:10.1371/journal.pntd.0004062PMID:26437177 Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans. - Dillon, James, Franks, Christopher J, Murray, Caitriona, Edwards, Richard J, Calahorro, Fernando, Ishihara, Takeshi, Katsura, Isao, Holden-Dye, Lindy and O'Connor, Vincent Published:2015Publication:The Journal of Biological ChemistryPage Range:1-28doi:10.1074/jbc.M114.606608PMID:25869139