Fleming, Tom P. - University of Southampton - Discipline of Biological Sciences

个人简介

Career history 1998-present: Professor of Developmental Biology. University of Southampton, UK. Senior Research Associate. Anatomy Department, University of Cambridge, UK. Demonstrator. University of Keele, UK. Academic qualifications PhD in Cell Biology. University of London, CNAA, South Bank Polytechnic,London, UK. BSc Zoology. University of Wales, Swansea, Wales.

研究领域

Embryo environment and developmental potential and health We are interested in how the environment of the oocyte and preimplantation embryo can influence its development and future long-term potential. We investigate how maternal diet (in vivo), maternal sickness (in vivo) or IVF-related culture conditions (in vitro) can affect blastocyst development including gene expression patterns, cell proliferation and cellular phenotype. We derive embryonic stem cell lines to further characterise environmental effects on developmental potential. We also examine long-term consequences of rodent preimplantation environment on subsequent fetal growth and gene expression, maternal nutrient provision, postnatal growth, cardiovascular and metabolic physiology, behaviour, immune reactivity. Our data indicate that programming of postnatal phenotype can derive from early embryonic environment which has important implications for embryo potential and fetal/postnatal health. Our studies comprise a range of molecular, epigenetic, cellular and physiological technologies on extra-embryonic and embryonic cell lineages and postnatal tissues. Mechanisms of early mammalian development We are also interested in the basic mechanisms regulating early mammalian development. Following fertilization, the egg undergoes a series of cell divisions to form a blastocyst which implants into the uterus wall. The blastocyst initially contains two types of cells, one an outer epithelium (trophectoderm) which gives rise to most of the placental tissues of the conceptus, the other, (inner cell mass), which gives rise to the entire foetus after implantation. Blastocyst formation is therefore an essential first step in our development. We use the mouse embryo to tackle the fundamental questions: How do different cell types expressing different genes and proteins emerge during development? What role is played by cell-cell interactions in this process? How do cells mature and differentiate into an epithelium, the commonest tissue in our bodies? We utilize mainly animal models for our research (principally the mouse) but also include human embryos where appropriate and under HFEA license. We have strong links with the School of Medicine at Southampton, particularly staff within DOHaD (Developmental Origins of Health and Disease) and the early human development and stem cell consortium within the university.

近期论文

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Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life - Velazquez, M.A., Smith, C.G.C., Smyth, N.R., Osmond, C. and Fleming, Thomas Published:2016Publication:Human ReproductionVolume:31, (9)Page Range:1970-80doi:10.1093/humrep/dew177PMID:27402911 Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation - Denisenko, Oleg, Lucas, Emma S., Sun, Congshan, Watkins, Adam J., Mar, Daniel, Bomsztyk, Karol and Fleming, Thomas Published:2016Publication:Biochimica et Biophysica ActaVolume:1859, (7)Page Range:906-913doi:10.1016/j.bbagrm.2016.04.001PMID:27060415 Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation - Denisenko, Oleg, Lucas, Emma S., Sun, Congshan, Watkins, Adam J., Mar, Daniel, Bomsztyk, Karol and Fleming, Tom P. Published:2016Publication:Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsVolume:1859, (7)Page Range:906-913doi:10.1016/j.bbagrm.2016.04.001 Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos - Gürke, Jacqueline, Schindler, Maria, Pendzialek, S. Mareike, Thieme, René, Grybel, Katarzyna J, Heller, Regine, Spengler, Katrin, Fleming, Thomas, Fischer, Bernd and Navarrete Santos, Anne Published:2016Publication:ReproductionVolume:151, (5)Page Range:465-476PMID:26836250 Maternal undernutrition affects neurogenesis in the foetal mouse brain - Airey, Chris J., Smith, Phoebe J., Restall, Katie, Marfy-Smith, Stephanie J., Fleming, Tom P. and Willaime-Morawek, Sandrine Published:2015Publication:International Journal of Developmental NeuroscienceVolume:47Page Range:72doi:10.1016/j.ijdevneu.2015.04.197PMID:26531520