Chad, John - University of Southampton - Discipline of Biological Sciences

个人简介

Career history Senior Lecturer, Biological Sciences, University of Southampton, UK. Senior Scientist, Sandoz Institute for Medical Research, UCLA, USA. Faculty Assistant Research Biologist, UCLA, USA. Post-doctoral Research Fellow, UCLA, USA. Academic qualifications PhD Neurophysiology, University of Southampton, UK. BSc Physiology & Biochemistry, University of Southampton, UK.

研究领域

My overall research interest is the processing and transformation of information within the nervous system. The long-term ambition being to understand the processes and principles which underlie the distribution and function of signalling systems within the architecture of the cell, and determine its fate. The overarching theme of my research over recent years has been the search for ways to extract pragmatically useful knowledge from the wealth of attainable neuroscience information. This is a central theme in many fields where new technologies generate vast data sets but understanding is lagging. Core to this theme is the modeling of function and dysfunction at a number of levels of abstraction. This is exemplified in the development and use of organotypic cultures of rodent brain for modelling neuropathology. This system retains synaptic connectivity, cell type diversity and electrical activity in a controlled in-vitro system. This work is part of long-standing collaborations within Biological Sciences and further afield, combining our imaging and tissue-culturing expertise to allow analysis of neuronal function. The success of this work translated into a spin-out company, Capsant Neurotechnologies, that we co-founded in 2002. We have advanced this work for the study of neuronal network dysfunction in organotypic cultures derived from transgenic mice that are allowing us to investigate the effects of mutants affecting synaptic signalling. This work also has important implications for the 3Rs agenda.

近期论文

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Integrated optical waveguides and inertial focussing microfluidics in silica for microflow cytometry applications - Butement, Jonathan, Hunt, Hamish, Rowe, David, Sessions, Neil, Clark, Owain, Hua, Ping, Murugan, G. Senthil, Chad, John and Wilkinson, James Published:2016Publication:Journal of Micromechanics and MicroengineeringVolume:26, (10)Page Range:1-12doi:10.1088/0960-1317/26/10/105004 Ptychographic coherent diffractive imaging with orthogonal probe relaxation - Odstrčil, Michal, Baksh, Peter, Boden, Stuart, Card, Rachel, Chad, John, Frey, Jeremy and Brocklesby, William Published:2016Publication:Optics ExpressVolume:24, (8)Page Range:8360-8369doi:10.1364/OE.24.008360 Bispyridinium compounds inhibit both muscle and neuronal nicotinic acetylcholine receptors in human cell lines - Ulrich, Henning, Ring, Avi, Strom, Bjorn Oddvar, Turner, Simon R., Timperley, Christopher M., Bird, Michael, Green, A. Christopher, Worek, Franz, Chad, John E. and Tattersall, John E.H. Published:2015Publication:PLoS ONEVolume:10, (8)Page Range:1-16doi:10.1371/journal.pone.0135811PMID:26274808 Evaluation of otoacoustic emissions as a biometric - Grabham, N.J., Swabey, M.A., Chambers, P., Lutman, M.E., White, N.M., Chad, J.E. and Beeby, S.P. Published:2012Publication:IEEE Transactions on Information Forensics and SecurityVolume:8, (1)Page Range:1-10doi:10.1109/TIFS.2012.2228854 A super-oscillatory lens optical microscope for subwavelength imaging - Rogers, Edward T.F., Lindberg, Jari, Roy, Tapashree, Savo, Salvatore, Chad, John E., Dennis, Mark R. and Zheludev, Nikolay I. Published:2012Publication:Nature MaterialsVolume:11, (5)Page Range:432-435doi:10.1038/nmat3280PMID:22447113