Jones, Keith T - University of Southampton - Discipline of Biological Sciences

个人简介

2013-present: Head of Biological Sciences. University of Southampton, UK. 2013-present: Professor in Cell Biology. University of Southampton, UK. 2008-present: Conjoint Professorship. Chinese Academy of Sciences. Institute of Zoology. 2013-present: Adjunct Professor of Physiology. University of Newcastle. Australia. 2008-2012: Professor in Human Physiology. School of Biomedical Sciences and Pharmacy, & Co-Director of the Priority Research Centre in Reproductive Biology, University of Newcastle, Australia. 2005-2008: Personal Chair in Reproductive Physiology. Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, UK. 2005: Reader in Reproductive Physiology. Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, UK. 2002-2005: Senior Lecturer. Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, UK. 1998-2002: Lecturer. Department of Physiological Sciences, University of Newcastle upon Tyne, UK 1997-1998: Senior Research Fellow. Department of Anatomy & Developmental Biology, University College London, UK. 1994-1997: Non-Clinical Scientist Grade 1. MRC Experimental Embryology & Teratology Unit, George's Hospital Medical School, London, UK.

研究领域

Oocytes are large single cells that have been used in many aspects of cell biology to uncover how cells work. My laboratory is concerned with how the process of meiosis happens in order to produce a healthy mature egg that is capable of being fertilized by the sperm at fertilization. In many species including our own meiosis lasts decades because it is punctuated by a protracted arrest in prophase. Hormonal signals cause meiotic resumption and completion of the first meiotic division, and the oocyte is then ovulated arrested at metaphase of the second meiotic division. A calcium signal at fertilization drives completion of the second meiotic division. We are concerned with the events going on inside the oocyte that are responsible for these stops and starts of the cell cycle.

近期论文

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The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis - Hamdan, Mukhri, Jones, Keith, Cheong, Ying and Lane, Simon Published:2016Publication:Scientific ReportsVolume:6, (36994)Page Range:1-8doi:10.1038/srep36994PMID:27841311 FACS-sorted putative oogonial stem cells from the ovary are neither DDX4-positive nor germ cells - Zarate-Garcia, Larissa, Lane, Simon I.R., Merriman-Jones, Julie A. and Jones, Keith T. Published:2016Publication:Scientific ReportsPage Range:1-28 DNA damage responses in mammalian oocytes - Collins, J.K and Jones, K.T Published:2016Publication:ReproductionPage Range:1-24doi:10.1530/REP-16-0069 DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint - Collins, Josie, Lane, Simon, Merriman-Jones, Julie and Jones, Keith Published:2015Publication:Nature CommunicationsVolume:6, (8553)Page Range:1-12doi:10.1038/ncomms9553PMID:26522232 Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice. - Yun, Y, Holt, JE, Lane, SIR, McLaughlin, EA, Merriman, JA and Jones, KT Published:2014Publication:Cell CycleVolume:13, (12)Page Range:1-10PMID:24758999 Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes - Yun, Y, Lane, SIR and Jones, KT Published:2014Publication:Development Volume:141, (1)Page Range:199-208doi:10.1242/dev.100206