Wootton, Stephen - University of Southampton

个人简介

Dr Wootton joined the University in 1984, having graduated in nutrition at the University of London and completing a PhD on the influence of nutrition and exercise on skeletal muscle energy metabolism. He has been responsible for developing nutrition within the undergraduate medical curriculum and played a leading role in the design and delivery of the principal national educational initiatives to improve the safety and effectiveness of doctors in delivering nutritional care. In his programme of research, he was brought the basic science of nutrition into clinical care using stable isotope tracer methodologies to study how diet, lifestyle and disease influence our demands for energy and nutrients, and how the way in which nutrients, especially lipids, are handled in health and in infectious and inflammatory disease. His studies have involved close collaboration with clinical colleagues across many specialties and span across the lifecourse to include studies in neonates and malnourished infants, in children with IBD and Cystic Fibrosis, in pregnancy, and in adults with IBD, HIV, obesity and diabetes. Through his work, and expertise in the clinical application of isotopic tracer methodologies, Dr Wootton serves as an advisor to the ICGN and the IAEA.

研究领域

Dr Wootton’s research has a focus on the way that diet, lifestyle and disease alter our demand for energy and nutrients and the way that nutrients are handled within the body. How dietary lipid is handled within the body is directly related to the development of malnutrition, cardiometabolic disease and obesity, yet the factors that determine the physiological and metabolic capability of an individual to process lipid from the diet are poorly understood. Using stable isotope tracer methodologies (13C), we have established an internationally recognized program of research that directly examines the processes by which lipids are digested and absorbed, partitioned from the circulating lipoproteins within peripheral tissues and their subsequent metabolism, oxidation or storage. Studies conducted in healthy children and adults have shown that these processes are influenced by age, gender, the type of fat in the background diet and physical activity. Studies in premature and malnourished infants and children with cystic fibrosis have demonstrated the clinical utility of differentiating between maldigestion and malabsorption in clinical management. Studies in dyslipidaemic patients with NIDDM and HIV have for the first time differentiated between the processes by which triglycerides may be cleared from circulating lipoproteins by lipoprotein lipase and the processes by which the products of hydrolysis are entrapped and taken up into the peripheral cell. Studies of the metabolism of n3-PUFA in men, women and premature have directly determined the capacity for EPA and DHA synthesis and how they are influenced by diet. In the same way, we have shown that a woman’s capacity to regulate and partition n3-PUFA in response to pregnancy will importantly determine the effective supply of EPA and DHA to her fetus. Studies in adults with Crohns disease have shown that n3-PUFA supplementation can improve both the inflammatory process and immune system, which may impact on bone health and clinical outcomes. Our focus now is to apply a nutritional lens to study the way that disease alters the demand for energy and nutrients in under-nourished neonates and children with IBD, and how standardized approaches to organizing and delivering nutritional care can manage the underlying disease processes, meet the nutritional demands of the child and lead to better growth, development and longer-term outcomes. In particular, we are studying the way that the gut microbiome can modulate the inflammatory processes within the gut and the degree of gut injury and bacterial translocation and how these processes can be influenced by nutritional care, including synbiotics.. Within the NIHR Biomedical Research Units at Southampton, we have established a new state-of-art Medical Mass Spectrometry Unit which brings together a range of novel analytical mass spectrometry platforms that include the capacity for dynamic studies of physiological state or metabolic flux (IRMS and FAMS), breathomics (SIFT-MS) as well as proteomic and lipidomic platforms. Taken together, these provide a unique resource for conducting human nutritional studies and biomarker discovery.

近期论文

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How to use: nutritional assessment in children - Wiskin, Anthony E., Johnson, Mark J., Leaf, Alison A., Wootton, Stephen A. and Beattie, R. Mark Published:2015Publication:Archives of Disease in Childhood: Education and Practice EditionVolume:100, (4)Page Range:204-209doi:10.1136/archdischild-2014-306516PMID:25516979 Obesity in breast cancer--what is the risk factor? - James, F.R., Wootton, S., Jackson, A., Wiseman, M., Copson, E.R. and Cutress, R.I. Published:2015Publication:European Journal of CancerVolume:51, (6)Page Range:705-720doi:10.1016/j.ejca.2015.01.057PMID:25747851 Postprandial effects of long-term niacin/laropiprant use on glucose and lipid metabolism and on cardiovascular risk in patients with polycystic ovary syndrome - Aye, M.M., Kilpatrick, E.S., Afolabi, P., Wootton, S.A., Rigby, A.S., Coady, A.M., Sandeman, D.D. and Atkin, S.L. Published:2014Publication:Diabetes, Obesity & Metabolism Volume:16, (6)Page Range:545-552doi:10.1111/dom.12255PMID:24401089 Quality control issues related to assessment of body composition - Wootton, Stephen, Durkin, Kesta and Jackson, Alan Published:2014Publication:Food and Nutrition BulletinVolume:35Page Range:S79-S85PMID:25069298 Tackling the obesity crisis: how do we 'measure up'? - Jackson, Alan A., Wiseman, Martin and Wootton, Stephen A. Published:2014Publication:Archives of Disease in ChildhoodVolume:99, (2)Page Range:95-98doi:10.1136/archdischild-2013-304034 PMID:24243929 The 'not so short-bowel syndrome': potential health problems in patients with an ileostomy - Ng, D.H.L., Pither, C.A.R., Wootton, S.A. and Stroud, M.A. Published:2013Publication:Colorectal DiseaseVolume:15, (9)Page Range:1154-1161doi:10.1111/codi.12252PMID:23602060 13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers - Afolabi, Paul, Wright, Mark, Wootton, Steve A. and Jackson, Alan A. Published:2013Publication:Isotopes in Environmental and Health StudiesVolume:49, (3)Page Range:346-356doi:10.1080/10256016.2013.803098PMID:23799253