Wilson, David - University of Southampton

个人简介

Professor Wilson was appointed to the Chair of Human Developmental Genetics in 2000. He completed general professional training in internal medicine and paediatrics before specialist training in Clinical Genetics. His PhD, that included a period of time in the University of Amsterdam, investigated DiGeorge Syndrome and helped identify the significance of 22q11 deletions and define the phenotype. This established an interest in human embryonic development and in particular cardiogenesis. Professor Wilson leads a group that investigates human embryonic development: current projects include the genetic basis for congenital heart disease, cardiac progenitor stem cells and the role of ALMS1 in the pathogenesis of the Alstroms syndrome phenotype. In Southampton, he has been Divisional Director of Human Genetics and co-founded the Centre for Human Development, Stem Cells and Regeneration. He helped establish the University of Southampton 4 year Integrated PhD programme in Stem Cells and is currently Deputy Director for Research (Faculty of Medicine).

研究领域

Professor Wilson’s group work within the Centre for Human Development, Stem Cells and Regeneration, and investigates the molecular genetic and cellular events during embryogenesis and the fetal period with a focus on cardiac development and cardiac genetics. Cardiac Development, Congenital Heart Disease and Stem Cells The group is interested in the development of the structure of the heart during normal development and the genes that control this process. This is investigated with access to human embryonic and fetal tissues which is considered necessary and extremely important given that although there are similarities between mammalian species, there are also differences. Ultimately the group is trying to establish the causes of malformations in humans. Potential students, post-doctoral scientists or clinician scientists who are interested in joining the group are encouraged to contact Professor Wilson.

近期论文

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Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life - Davies, Elizabeth R., Kelly, Joanne F., Howarth, Peter H., Wilson, David, Holgate, Stephen, Davies, Donna E., Whitsett, Jeffrey A. and Haitchi, Hans Michael Published:2016Publication:Journal of Clinical Investigation InsightVolume:1, (11)Page Range:1-16doi:10.1172/jci.insight.87632 Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis - Inglis, Stefanie, Christensen, David, Wilson, David I., Kanczler, Janos M. and Oreffo, Richard O.C. Published:2016Publication:Stem Cell Research & TherapyVolume:7, (13)Page Range:1-16doi:10.1186/s13287-015-0270-3PMID:26781715 Regionally-derived cell populations and skeletal stem cells from human foetal femora exhibit specific osteochondral and multi-lineage differentiation capacity in vitro and ex vivo - Gothard, David, Cheung, Kelvin, Kanczler, Janos M., Wilson, David I. and Oreffo, Richard O.C. Published:2015Publication:Stem Cell Research & TherapyVolume:6, (251)Page Range:1-17doi:10.1186/s13287-015-0247-2PMID:26684339 Probing the epigenetic regulation of HIF-1? transcription in developing tissue - Mistry, Ishna N., Smith, Peter J.S., Wilson, David I. and Tavassoli, Ali Published:2015Publication:Molecular BioSystemsPage Range:1-6doi:10.1039/C5MB00281HPMID:26066786