Williams, Anthony - University of Southampton

个人简介

Dr Williams was appointed as Reader in Clinical Immunology and Allergy in 2009. He graduated in Medicine from University College London and undertook general medicine training in Cardiff. He then specialised in Clinical Immunology and Allergy at Oxford and completed his PhD in the MHC class I antigen presentation at the Weatherall Institute of Molecular Medicine, University of Oxford. He moved to Southampton to undertake a Wellcome Clinician Scientist Fellowship and develop a Translational Clinical Immunology programme through the Faculty of Medicine. Dr Williams leads a Translational Immunology group within the Experimental Cancer Medicine Centre (ECMC), CRUK Clinical Centre, Southampton that applies cutting edge immunological monitoring analyses (immunometry) to clinical trials that are evaluating immunological modifiers in haematological and solid organ malignancies (i.e. DNA vaccines, monoclonal antibodies and adoptive cellular therapies). He also has translational research programmes in Paediatric Infectious diseases, particularly primary immunodeficiency, and allergic disease. Commercial partnerships with GSK Bio and Merck Serono have been established for the application of immunometry to multi centre vaccine trials. He is a Clinical Consultant in Immunology and Allergy and Head of the Regional Clinical Immunology Laboratory at Southampton University Hospital Trust.

研究领域

Dr Williams’ research encompasses basic science, translational assessment and clinical adoption of diagnostic and therapeutic interventions that stem from the adaptation of discovery science in Human Immunology. Immunological end points for Clinical Trials In collaboration with Professor Ottensmeier (ECMC Director) and the Experimental Cancer Medicine Centre, the translational research group have developed a portfolio of validated immunological end point assessments that are utilised in DNA vaccine, monoclonal antibody and small molecule studies. These assessments evaluate antigen specific CD4 and CD8 responses by tetramer, intracellular cytokine, secreted protein array and phenotypic enumeration. Figure 1 shows one such example where polyfunctional T cells against specific antigens maybe enumerated and utilised as biomarkers of vaccine responsiveness. These studies also extend to important rarer cell populations including functional assessments of regulatory T cells (Tregs), invariant NKT cells (iNKTs), inflammatory monocytes, myeloid dendritic cell (mDC), plasmacytoid dendritic cells (pDC) and Natural Killer cells (NK’s). These assessment platforms are currently being shared with commercial partners (e.g. MerckSerono and Geron Corp) for multi centre studies and first in man evaluations. Host Defence, Infection and Immunodeficiency In collaboration with Dr Saul Faust (Wellcome Trust Clinical Research Facility Director [WTCRF] and Senior Lecturer in Paediatric Infection and Immunity) a joint research team has been established to evaluate host defence in severe, persistent, unusual or recurrent paediatric sepsis. The programme has focused on evaluating the innate immune system of such children, partnering functional characterisations with genomic profiling through exome analysis of index cases. These studies have developed an array of new analysis tools that are currently being applied to other clinical infectious disease settings (Cystic Fibrosis and Adult onset Primary Immunodeficiency) and through commercial partnerships (GSK Bio) for the interrogation of new vaccine interventions.

近期论文

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IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus - Drennan, S., D'Avola, A., Gao, Y., Weigel, C., Chrysostomou, E., Steele, A.J., Zenz, T., Plass, C., Johnson, P.W., Williams, A.O., Packham, G., Stevenson, F.K., Oakes, C.C. and Forconi, F. Published:2017Publication:LeukemiaPage Range:1-9doi:10.1038/leu.2016.356PMID:27890932 Genes implicated in thiopurine-induced toxicity: comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort - Coelho, Tracy, Andreoletti, Gaia, Ashton, James, Batra, Akshay, Afzal, Nadeem, Gao, Yifang, Williams, Anthony, Beattie, Robert and Ennis, Sarah Published:2016Publication:Scientific ReportsVolume:6Page Range:34658 Precision molecular diagnosis defines specific therapy in combined immunodeficiency with megaloblastic anaemia secondary to MTHFD1 deficiency - Ramakrishnan, Kesava, Pengelly, Reuben, Gao, Yifang, Morgan, Mary, Patel, Sanjay, Davies, Graham, Ennis , Sarah, Faust, Saul and Williams, Tony Published:2016Publication:Journal of Allergy and Clinical Immunology: in PracticeVolume:4, (6)Page Range:1160-1166.e10doi:10.1016/j.jaip.2016.07.014PMID:27707659 Bone marrow transplantation for MHC class I deficiency corrects T cell immunity but dissociates NK cell repertoire formation from function - Gao, Yifang, Arkwright, Peter D., Darley, Rachel, Cazaly, Angelica, Harrison, Rebecca J., Mant, Alexandra, Cant, Andrew J., Gadola, Stephan, Elliott, Timothy, Khakoo, Salim and Williams, Anthony Published:2016Publication:Journal of Allergy and Clinical ImmunologyPage Range:1-16doi:10.1016/j.jaci.2016.06.029 Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase delta syndrome - Rae, William, Ramakrishnan, Kesava, Gao, Yifang, Ashton-Key, Martin, Pengelly, Reuben, Patel, Sanjay V., Ennis, Sarah, Williams, Anthony P. and Faust, Saul Published:2016Publication:Clinical ImmunologyVolume:171Page Range:38-40doi:10.1016/j.clim.2016.07.017PMID:27444043