Willaime-Morawek, Sandrine - University of Southampton

个人简介

Having graduated in Biology from the Ecole Normale Supérieure de Lyon, France, she completed her PhD in Neurosciences at the University of Paris VI, France, in 2003, working on intracellular signalling pathways during neuronal apoptosis under the supervision of Prof Jean Mariani and Dr Bernard Brugg. She studied the effect of a second messenger, ceramide, on the MAP kinase pathways and how these signalling pathways could influence the choice of a neuron between survival and apoptosis. She then moved on as postdoctoral fellow to Professor Derek van der Kooy’s team in Toronto, Canada, working on neural stem cells during the development of the brain, in the adult brain and in different pathological conditions, before being appointed in Southampton. Dr Willaime-Morawek leads a group that investigates the role of the microenvironment on the activity of stem cells in the developing, adult or pathological brain. She is part of the Centre for Human Development, Stem Cells & Regeneration and her research is based within the Southampton General Hospital; her basic biology group comprises clinical, non-clinical and industry scientists.

研究领域

Dr Willaime-Morawek research has a focus on the role of the microenvironment on the activity of stem cells in the developing, adult or pathological brain, specifically in brain tumours. Role of parental diet on regulation of offspring foetal neural stem cells and brain development (in collaboration with Tom Fleming, Judith Eckert, Adam Watkins) Early studies suggest an effect of the maternal low protein diet on the overall brain growth and cell cycle. More recently, generation of astrocytes and mature neurons in postnatal brain has been shown to be affected by protein restriction during gestation. These and our preliminary data suggest that neural stem cells activity might be affected by a maternal low protein diet. Our hypothesis is that a maternal or paternal low protein or high fat diet before or during gestation, and possibly just during the periconceptional period, affects the development of the brain and the regulation of neural stem cells across life. The aims of the project are to define the effects of a parental low protein or high fat diet on the development of the brain and the regulation of neural stem cells, at cellular and organ levels. In particular, the project examines whether the parental diet regulates in vitro and in vivo proliferation, self-renewal, differentiation and migration of the offspring neural stem cells at different ages, using techniques such as sphere assay, immunocyto/histochemistry, FACS, videomicroscopy, migration assays, in vivo labelling and imaging. The project will also examine what the critical window is during development of the brain for low protein and high fat parental diet to affect neural stem cells and brain development.

近期论文

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Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in glioblastoma sphere-forming cells. - Siney, Elodie J., Holden, Alexander, Casselden, Elizabeth, Bulstrode, Harry, Thomas, Gareth J. and Willaime-Morawek, Sandrine Published:2016Publication:Molecular NeurobiologyPage Range:1-13doi:10.1007/s12035-016-0053-6PMID:27541285 The use of human neurons for novel drug discovery in dementia research - Vargas-Caballero, Mariana, Willaime-Morawek, Sandrine, Gomez-Nicola, Diego, Perry, V. Hugh, Bulters, Diedrik and Mudher, Amrit Published:2016Publication:Expert Opinion on Drug DiscoveryPage Range:1-35doi:10.1517/17460441.2016.1154528PMID:26878555 Maternal undernutrition affects neurogenesis in the foetal mouse brain - Airey, Chris J., Smith, Phoebe J., Restall, Katie, Marfy-Smith, Stephanie J., Fleming, Tom P. and Willaime-Morawek, Sandrine Published:2015Publication:International Journal of Developmental NeuroscienceVolume:47Page Range:72doi:10.1016/j.ijdevneu.2015.04.197PMID:26531520 Novel association between microglia and stem cells in human gliomas: a contributor to tumour proliferation? - Noorani, Imran, Petty, Gareth, Grundy, Paul L, Sharpe, Geoff, Willaime-Morawek, Sandrine, Harris, Scott, Thomas, Gareth J, Nicoll, James AR and Boche, Delphine Published:2015Publication:The Journal of Pathology: Clinical ResearchPage Range:1-9doi:10.1002/CJP2.7 A-Disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells - Bulstrode, Harry, Jones, Louise M, Siney, Elodie J, Sampson, Jessica M, Ludwig, Andreas, Gray, William P and Willaime-Morawek, Sandrine Published:2012Publication:Cancer LettersVolume:326, (1)Page Range:79-87doi:10.1016/j.canlet.2012.07.022PMID:22841667