Wilkinson, Tom - University of Southampton

个人简介

Dr Tom Wilkinson was appointed as Consultant and Senior Lecturer to a joint post held between the Respiratory and Nutrition BRUs and allied to the faculty of medicine in July 2010. He was subsequently awarded a HEFCE New Blood Senior Lectureship on the basis of his track record of clinically focused research in COPD and respiratory infection having been recognised as European COPD researcher of the year prior to his move from UCL. Since his appointment in Southampton Dr Wilkinson has raised over £7m for COPD and infection research. Dr Wilkinson’s work focuses on understanding the mechanisms which contribute to the vulnerability to and impact of respiratory infections in patients with chronic lung disease. He is co-lead of the Southampton COPD group and is establishing a cohort of deeply phenotyped patients with COPD to determine the mechanisms driving exacerbations of this disease. Close collaborations in Southampton, London and Oxford have been established to uncover the interaction between nutritional status, immune responses and infection. He has contributed to the establishment of unique ex-vivo and in vivo infection challenge models and is clinical lead on the EVITA programme (ex-vivo models of infection and therapeutics in airways disease) which has established a translational pathway for novel therapies from simple cell systems to complex human viral challenge models.

研究领域

Nutrition, Infection and Immunology The human body is under the constant threat of infection and there is increasing recognition that the nutritional state is a key modulator of our immune responses to this attack. Malnutrition is a common phenomenon globally and in certain chronic disease states such as COPD. A unique collaboration between experts in nutrition, immunology, microbiology and respiratory medicine is working towards understanding the complex interactions between these factors.

近期论文

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Human lung fibroblasts present bacterial antigen to autologous lung T helper cells - Hutton, Andrew J., Polak, Marta E., Spalluto, C. Mirella, Wallington, Joshua C., Pickard, Christopher, Staples, Karl J., Warner, Jane A. and Wilkinson, Tom M.A. Published:2017Publication:The Journal of ImmunologyVolume:198, (1)Page Range:110-118doi:10.4049/jimmunol.1600602PMID:27895174 Relationships between mucosal antibodies, non-typeable haemophilus influenzae (NTHi) infection and airway inflammation in COPD - Staples, Karl J., Taylor, Stephen, Thomas, Steve, Leung, Stephanie, Cox, Karen, Pascal, Thierry G., Ostridge, Kristoffer, Welch, Lindsay, Tuck, Andrew C, Clarke, Stuart C, Gorringe, Andrew and Wilkinson, Thomas Published:2016Publication:PLoS ONEPage Range:1-17doi:10.1371/journal.pone.0167250PMID:27898728 Seasonality, risk-factors and burden of community-acquired pneumonia in COPD patients: A population database study using linked healthcare records - Williams, Nicholas P, Coombs, Ngaire A, Johnson, Matthew, Josephs, Lynn, Rigge, Lucy, Staples, Karl J., Thomas, Mike and Wilkinson, Tom M A Published:2016Publication:International Journal of Chronic Obstructive Pulmonary DiseasePage Range:1-23 Novel expression of a functional trimeric fragment of human SP-A with efficacy in neutralisation of RSV - Watson, Alastair, Kronqvist, Nina, Spalluto, C. Mirella, Griffiths, Mark, Staples, Karl J., Wilkinson, Tom, Holmskov, Uffe, Sorensen, Grith L., Rising, Anna, Johansson, Jan, Madsen, Jens and Clark, Howard Published:2016Publication:ImmunobiologyPage Range:1-8doi:10.1016/j.imbio.2016.10.015 Viral inhibition of bacterial phagocytosis by human macrophages: redundant role of CD36 - Cooper, Grace E, Pounce, Zoe C, Wallington, Joshua, Bastidas Legarda, Leidy Y., Nicholas, Benjamin, Chidomere, Chiamaka, Robinson, Emily C., Martin, Kirstin, Tocheva, Anna S., Christodoulides, Myron, Djukanovic, Ratko, Wilkinson, Thomas M.A. and Staples, Karl J Published:2016Publication:PLoS ONEVolume:11, (10)Page Range:1-15doi:10.1371/journal.pone.0163889PMID:27701435 Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases - Ostridge, Kristoffer, Williams, Nicholas, Kim, Viktoriya, Harden, Stephen, Bourne, Simon, Coombs, Ngaire A., Elkington, Paul T., Estepar, Raul San Jose, Washko, George, Staples, Karl J. and Wilkinson, Tom M.A. Published:2016Publication:Respiratory ResearchVolume:17, (92)Page Range:1-8doi:10.1186/s12931-016-0402-zPMID:27460105