West, Jonathan James - University of Southampton

个人简介

Jonathan has a five-year Institute for Life Sciences Research Fellowship to establish his research activity on Microfluidic Single Cell Analytics. This involves developing microfluidic platforms to investigate medically-relevant cellular systems. The challenges associated with each application inform our understanding of microfluidic particle transport and drive the development of innovative solutions. Jonathan has a multi-disciplinary background, starting with a BSc in Medical Microbiology from the University of Edinburgh, before taking up the challenge of a PhD (“Microsystems for Genetic Diagnostics”) at the National Microelectronics Research Centre, University College Cork. In 2003, his interest in technology commercialisation led him to INEX, the Institute for Nanotechnology Exploitation. Equipped with this industrial experience, Jonathan then moved to ISAS in Dortmund, to work with Prof. Andreas Manz, who pioneered the micro Total Analysis System/Lab on a Chip field. In 2008 Jonathan established his independent Life Sciences research activity within the Miniaturisation Group and was promoted to Junior Group leader in 2010. His research group focussed on the development of organ on a chip technologies and microfluidic single cell analytics. In 2012 Jonathan was appointed as an Institute for Life Science research lecturer at the University of Southampton, to bridge the Hybrid Biodevices and Medicine research activities.

研究领域

Microfluidics Single Cell Analytics Jonathan leads a multidisciplinary team developing innovative microfluidic platforms to analyse cellular systems. As microfluidic dimensions approach the length scale of a single cell, flow becomes laminar and manipulations become deterministic to enable exquisite spatial and temporal control. This quality can be used to provide superior assay resolution to address previously intractable questions in cell biology. Beyond this, array methodologies or continuous flow operation can deliver the throughput necessary for large scale screens to survey the variety within cell populations.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Preparation of neuronal co-cultures with single cell precision - Dinh, Ngoc-Duy, Chiang, Ya-Yu, Hardelauf, Heike, Waide, Sarah, Janasek, Dirk and West, Jonathan Published:2014Publication:Journal of Visualized ExperimentsVolume:, (87)Page Range:e51389doi:10.3791/51389 Micropatterning neuronal networks - Hardelauf, Heike, Waide, Sarah, Sisnaiske, Julia, Jacob, Peter, Hausherr, Vanessa, Schöbel, Nicole, Janasek, Dirk, van Thriel, Christoph and West, Jonathan Published:2014Publication:The AnalystVolume:139, (13)Page Range:3256-3264doi:10.1039/c4an00608a Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling - Chiang, Ya-Yu and West, Jonathan Published:2013Publication:Lab on a ChipVolume:13, (6)Page Range:1031-1034doi:10.1039/C3LC41297K Microfluidic construction of minimalistic neuronal co-cultures - Dinh, N.-D., Chiang, Y.-Y., Hardelauf, H., Baumann, J., Jackson, E., Waide, S., Sisnaiske, J., Frimat, J.-P., van Thriel, C., Janasek, D., Peyrin, J.-M. and West, J. Published:2013Publication:Lab on a Chipdoi:10.1039/C3LC41224E Micropatterned neuronal cells - a new tool for neurotoxicity testing and drug discovery in vitro - Sisnaiske, J., Hardelauf, H., Frimat, J. P., Waide, S., Schobel, N., Hausherr, V., Baumann, J., Dinh, N. D., Hengstler, J. G., West, J. and van Thriel, C. Published:2012Publication:Naunyn-Schmiedebergs Archives of PharmacologyVolume:385Page Range:p.91 High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes - Hardelauf, H., Sisnaiske, J., Taghipour-Anvari, A.A., Jacob, P., Drabiniok, E., Marggraf, U., Frimat, J.P., Hengstler, J.G., Neyer, A., van Thriel, C. and West, J. Published:2011Publication:Lab on a ChipVolume:11, (16)Page Range:2763-2771doi:10.1039/C1LC20257J