Warner, Jane - University of Southampton

个人简介

After finishing her PhD on the anti-inflammatory effects of bee venom peptides at UCL Dr Warner undertook a post-doctoral fellowship in the Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine in Baltimore Maryland. She worked with Dr Larry Lichtenstein and Dr Don MacGlashan on IgE dependent signaling in human basophils and isolated mast cells from a range of human tissues characterizing their mediator release. Returning to the UK in 1990 she established a research group first in the School of Biological Sciences and more recently in the School of Medicine. Work has revolved around the role of small airways and surrounding parenchyma in asthma and COPD using a range of ex vivo techniques. She has extensive expertise in working with human lung tissue explants and characterizing the effects of different drugs on the inflammatory response. She has also isolated a range of cells from human lung including mast cells, macrophages, fibroblasts and T cells.

研究领域

Chronic lung diseases such as asthma, COPD and pulmonary fibrosis are a major cause of mortality and morbidity in the Western world and their incidence is still increasing. Understanding the fundamental changes that underpin these conditions may lead to the development of new drugs or approaches to treating these diseases. Typically research has focused on the large airways but our work highlights the role of the small airways and surrounding tissue in both asthma and COPD. Current projects include:- (a) Novel inflammatory mechanisms in COPD. Collaboration with Chris Pickared. This study is looking at the role of oxidative stress in the pathogenesis of COPD and the potential development of autoimmune responses. (b) Role of peptides of the renin angiotensin system in the airways. Collaboration with Lynn Andrews and Chris Torrens (HDH) The identification of angiotensin converting enzyme 2 (ACE2) in 2000 suggests a wide range of peptides may be generated in the airways and influence inflammatory pathways. This project will examine the distribution of ACE and ACE2 and the distinctions between the upper and lower airways. (c) Modulators of airway and vascular smooth muscle contraction Collaboration with ChrisTorrens and Tony Sampson. This project aims to characterize some of the orphan GPCR found on smooth muscle cells in the airways and vasculature looking to identify the expression of the receptors by immunohistochemistry and PCR and characterize their functional responses. Areas of interest include the pro and anti-inflammatory lipids and novel approaches to dilating the airways and vasculature. (d) Novel mechanisms for the regulation of human lung fibroblasts. Collaboration with Lynn Andrews and Tony Sampson. This project aims to identify novel receptors on human lung fibroblasts from the proximal and distal airways and develop new strategies to target fibrosis in the airways.

近期论文

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Human lung fibroblasts present bacterial antigen to autologous lung T helper cells - Hutton, Andrew J., Polak, Marta E., Spalluto, C. Mirella, Wallington, Joshua C., Pickard, Christopher, Staples, Karl J., Warner, Jane A. and Wilkinson, Tom M.A. Published:2017Publication:The Journal of ImmunologyVolume:198, (1)Page Range:110-118doi:10.4049/jimmunol.1600602PMID:27895174 Airway and peripheral uPAR is elevated in asthma, and identifies a severe, non-atopic subset of patients - Portelli, Michael A., Moseley, Christopher, Stewart, Ceri E., Postma, Dirkje S., Howarth, Peter, Warner, Jane A., Holloway, John Q., Koppelman, Gerard H., Brightling, Chris and Sayers, Ian Published:2016Publication:AllergyPage Range:1-10doi:10.1111/all.13046 Three-dimensional characterisation of fibroblast foci in idiopathic pulmonary fibrosis - Jones, Mark, Fabre, Aurelie, Schneider, Philipp, Cinetto, Francesco, Sgalla, Giacomo, Mavrogordato, Mark, Jogai, Sanjay, Alzetani, Aiman, Marshall, Benjamin, O'Reilly, Katherine, Warner, Jane, Lackie, Peter, Davies, Donna, Hansell, David, Nicholson, Andrew, Sinclair, Ian, Brown, Kevin and Richeldi, Luca Published:2016Publication:JCI InsightPage Range:1-11doi:10.1172/jci.insight.86375 Three dimensional imaging of paraffin embedded human lung tissue samples by micro-computed tomography - Scott, A.E., Vasilescu, D.M., Seal, K.A.D., Keyes, S.D., Mavrogordato, M.N., Hogg, J.C., Sinclair, I., Warner, J.A., Hackett, T.L. and Lackie, P.M. Published:2015Publication:PLoS ONEPage Range:1-10doi:10.1371/journal.pone.0126230 Interleukin-13, but not indomethacin, increases cysteinyl-leukotriene synthesis in human lung macrophages - Jackson, Sarah E., Holloway, John W., Warner, Jane A. and Sampson, Anthony P. Published:2011Publication:Journal of AllergyVolume:2012Page Range:1-6doi:10.1155/2012/348741PMID:22121385