Rijn, Bas Van - University of Southampton

个人简介

Bas van Rijn completed his undergraduate training in Medicine at Utrecht University in The Netherlands, and subsequently obtained his MD in 2002. During his studies he conducted research on the role of oxidative stress in severe pre-eclampsia in Utrecht and at St Thomas’ Hospital, Kings College London. He was awarded an Erasmus/Socrates Scholarship of the European Union (2000) and the Talma Eykman Award for Scientific Excellence (2001) by Utrecht University for his work on detection of placental and circulating free radicals by electron paramagnetic resonance (EPR) spin-trapping with at the Faculty of Physics and Astronomy of Utrecht University. In 2003 he obtained a Clinical Research/Ph.D. Scholarship by The Netherlands Organization for Health Research for research on maternal constitutional factors underlying pregnancy outcome and cardiovascular health and was awarded his PhD in 2008. After a further 3 years of clinical training at the University Medical Centre Utrecht and St Antonius Hospital Nieuwegein, both in The Netherlands, he moved to Southampton in and currently holds a position as Clinical Lecturer in Obstetrics and Gynaecology (as per October 2012). His research includes clinical studies on the interplay between cardiovascular health, placental development and maternal-fetal outcome, as well as translational studies on the impact of maternal health on fetal cardiovascular development and epigenetics.

研究领域

Pregnancy as a window of opportunity for early-life prevention of cardiovascular disease Cardiovascular health concerns us all, simply because cardiovascular diseases (CVD) are the number 1 cause of death in both men and women globally. In recent years, health during the reproductive life cycle is increasingly recognized as a window of opportunity to prevent early development of vascular changes that lead to later-life CV risk. Several reproductive disorders, including polycystic ovary syndrome, pre-eclampsia, gestational diabetes and placental disorders have the potential to unmask underlying CV risk in young women. Maternal health, pregnancy outcome and long-term cardiovascular risk Recently, we and others identified several important risk factors for CVD in women that experience common complications of pregnancy (e.g. pre-eclampsia, placental abruption and fetal growth restriction). This has led to changes in follow-up of pregnant women after delivery, development of a national guideline (NL) and public awareness among patient organisations. Current research is focussed on the link between cardiovascular health and placental development and the fetal origins of cardiovascular disease. This includes research on epigenetic control of placental nutrient transport, placental inflammation in response to overnutrition, epigenetic programming of fetal heart development, ultrasound evaluation of fetal cardiac function during pregnancy in mothers with obesity and diabetes and the study of microRNAs as biomarkers and translational targets in pregnancy-associated cardiovascular complications, which was awarded an Academy for Medical Sciences’ Starter Grant for Clinical Lecturers, supported by the British Heart Foundation, Medical Research Council, Arthritis Research UK, Prostate Cancer UK and the Wellcome Trust.

近期论文

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The 'Developmental Origins' Hypothesis: relevance to the obstetrician and gynecologist - Kermack, A., van Rijn, B., Calder, P., Cameron, I.T. and Macklon, N. Published:2015Publication:Journal of Developmental Origins of Health and DiseaseVolume:6, (5)Page Range:415-424doi:10.1017/S2040174415001324PMID:26347389 The ‘Developmental Origins’ hypothesis: relevance to the obstetrician and gynecologist - Kermack, A. J., Van Rijn, B. B., Houghton, F. D., Calder, P. C., Cameron, I. T. and Macklon, N. S. Published:2015Publication:Journal of Developmental Origins of Health and DiseaseVolume:6, (5)Page Range:415-424doi:10.1017/S2040174415001324 Determinants of future cardiovascular health in women with a history of preeclampsia - Zoet, Gerbrand A., Koster, Maria P.H., Velthuis, Birgitta K., de Groot, Christianne J.M., Maas, Angela H.E.M., Fauser, Bart C.J.M., Franx, Arie and van Rijn, Bas B. Published:2015Publication:MaturitasVolume:82, (2)Page Range:153-161doi:10.1016/j.maturitas.2015.07.004PMID:26255680 Biopsy techniques to study the human placental bed - Veerbeek, J.H.W., Post Uiterweer, E.D., Nikkels, P.G.J., Koenen, S.V., van der Zalm, M., Koster, M.P.H., Burton, G.J., van Rijn, B.B. and Franx, A. Published:2015Publication:PlacentaPage Range:1-8doi:10.1016/j.placenta.2015.05.008PMID:26076963 PLD.31. The rising rate of labour induction: what is causing the trend? - Walker, S., van Rijn, Bas B., Macklon , N. and Howe, D. Published:2014Publication:Archives of Disease in Childhood - Fetal and Neonatal EditionVolume:99Page Range:p.A115doi:10.1136/archdischild-2014-306576.331PMID:25020969