Underwood, Tim - University of Southampton

个人简介

Tim Underwood was appointed as an MRC Clinician Scientist in 2011. He graduated from the Royal Free Hospital School of Medicine (London) in 1998 with a first class BSc in Molecular Medicine and the Gant Medal for Surgery. He trained in General Surgery in London and Southampton before completing a PhD in the Blaydes laboratory in 2007. He has subsequently specialized in Upper Gastrointestinal Surgery with a special interest in oesophageal cancer and minimally invasive surgical techniques. He was awarded the Association of Surgeons of GB & I prize and medal for his outstanding performance in the final FRCS exams in February 2011. Tim Underwood was appointed as an NIHR Clinical Lecturer in Surgery in 2008 and developed a research program to investigate stromal-epithelial interactions in the oesophagus. He has developed a 3D organotypic model of the human oesophagus and is currently using this to study the role of cancer associated fibroblasts in the development and maintenance of oesophageal cancer.

研究领域

Mr Underwood’s research has a focus on the development and progression of upper GI cancer, in particular oesophageal cancer. His surgical science interests include minimally invasive surgery and pre and post-operative predictors of outcome after oesophagogastic surgery. Stromal-epithelial interactions in oesophageal cancer Oesophageal adenocarcinoma (EAC) is the fastest rising cancer in the UK; the incidence has doubled in men over the last 25 years. At presentation the majority of oesophageal tumours will have invaded through the wall of the oesophagus, meaning that only 20% of patients will be suitable for curative treatment. Early invasion leads to disseminated disease and an overall five year survival of only 7%, one of the lowest of any cancer.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis - Mellone, Massimiliano, Hanley, Christopher, Thirdborough, Stephen, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steven, Jenei, Veronika, Moutasim, Karwan, Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma, Gil, Jesus, Ottensmeier, Christian and Thomas, Gareth Published:2016Publication:AgingPage Range:1-19doi:10.18632/aging.101127PMID:27992856 Mutational signatures in esophageal adenocarcinoma reveal etiologically distinct subgroups with therapeutic relevance - Secrier, Maria, Li, Xiaodun, de Silva, Nadeera, Eldridge, Matthew D., Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Nuria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P., Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A.W., Lynch, Andy G., Tavare, Simon and Fitzgerald, Rebecca C. Published:2016Publication:Nature GeneticsVolume:48, (10)Page Range:1131-41 Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 - Garcia, Edwin, Hayden, Annette, Birts, Charles, Britton, Edward, Cowie, Andrew, Pickard, Karen, Mellone, Massimiliano, Choh, Clarisa, Derouet, Mathieu, Duriez, Patrick, Noble, Fergus, White, Michael J., Primrose, John, Strefford, Jonathan C., Rose-Zerilli, Matthew, Thomas, Gareth, Ang, Yeng, Sharrocks, Andrew D., Fitzgerald, Rebecca C. and Underwood, Timothy J. Published:2016Publication:Scientific reportsVolume:6, (32417)Page Range:1-12doi:10.1038/srep32417PMID:27600491 Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma - Noble, Fergus, Mellows, Toby, McCormick Matthews, Leo H., Bateman, Adrian, Harris, Scott, Underwood, Tim, Byrne, James P., Bailey, Ian S., Sharland, Donna M., Kelly, Jamie J., Primrose, John N., Sahota, Surinder S., Bateman, Andrew R., Thomas, Gareth J and Ottensmeier, Christian H. Published:2016Publication:Cancer Immunology ImmunotherapyVolume:65, (6)Page Range:651-662doi:10.1007/s00262-016-1826-5PMID:27020682