Tod, Jo - University of Southampton

个人简介

Jo Tod was appointed as an NIHR Clinical Lecturer in Gastroenterology and Hepatology in March 2014. She graduated from Imperial College School of Medicine London in 2004 with MBBS Honours and a 1st class BSc in Endocrinology. She undertook her General Medical training in the Wessex deanery and obtained Membership to the Royal College of Physicians in 2007. Jo has held an NTN in Gastroenterology on the Wessex Specialist Training rotation since 2008 and is due to commence a 12-month Hepatology Subspecialty fellowship post in Sept 2015. In 2011 she was awarded an MRC Clinical Training Fellowship to undertake a PhD studying molecular mechanisms of invasion in pancreatic cancer (PC) under the supervision of Professor Gareth Thomas and Dr David Fine in the Cancer Sciences Unit at University of Southampton. Jo’s research findings have been presented at local, national and international conferences. She won the Lord Smith Medal at the PSGBI in 2010 and was invited as a Keynote Speaker to the European Pancreatic Conference in 2014. Jo has been involved in public engagement including an oral presentation to MPs at the House of Commons All Parliamentary Group on Pancreatic Cancer. Jo has established a strong research foundation in Pancreatic Cancer, including generating a pancreatic tissue bank and leading a multi-centre European Pancreas2000 project to examine the tumour biology of long survivors of PC, for which she was awarded a Future Leaders Award from Pancreatic Cancer UK. Since appointment she has been awarded a PCUK/Grand Charity Medical Research Grant and a Planets Charity Grant to fund her ongoing research projects.

研究领域

Our research focuses on cancer cell invasion with particular emphasis on the tumour microenvironment. The work is carried out in the Experimental Pathology Group led by Professor Gareth Thomas. Dr Tod’s principle research interest is pancreatic cancer. Pancreatic adenocarcinoma (PC) has one of the worst outcomes of any cancer with a 5-year survival of only 3.7%. It is clear that new molecular-based treatments are required, in order to develop these we need a better understanding of the underlying pancreatic cancer biology.

近期论文

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Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis - Mellone, Massimiliano, Hanley, Christopher, Thirdborough, Stephen, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steven, Jenei, Veronika, Moutasim, Karwan, Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma, Gil, Jesus, Ottensmeier, Christian and Thomas, Gareth Published:2016Publication:AgingPage Range:1-19doi:10.18632/aging.101127PMID:27992856 Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma - McCormick Matthews, L.H., Noble, F., Tod, J., Jaynes, E., Harris, S., Primrose, J.N., Ottensmeier, C.H. , Thomas, G.J. and Underwood, T.J. Published:2015Publication:British Journal of CancerVolume:113, (1)Page Range:107-118doi:10.1038/bjc.2015.179 Suppression of hedgehog signalling promotes pro-tumourigenic integrin expression and function - Moutasim, Karwan A., Mellows, Toby, Mellone, Massimiliano, Lopez, Marie-Antoinette, Tod, Joanne, Kiely, Philip C., Sapienza, Karen, Greco, Azzura, Neill, Graham, Violette, Shelia, Weinreb, Paul, Marshall, John, Ottensmeier, Christian H., Sayan, A.E., Jenei, V. and Thomas, Gareth J. Published:2014Publication:The Journal of PathologyVolume:233, (2)Page Range:196-208doi:10.1002/path.4342PMID:24573955 Tumor-stromal interactions in pancreatic cancer - Tod, Jo, Jenei, Veronika, Thomas, Gareth and Fine, David Published:2013Publication:PancreatologyVolume:13, (1)Page Range:1-7doi:10.1016/j.pan.2012.11.311PMID:23395563