Tebruegge, Marc - University of Southampton

个人简介

Marc Tebruegge began his medical studies at the University of Frankfurt Medical School. During his undergraduate medical training he spent the second clinical year at University College London (UCL), and his final year at the University of New South Wales (Sydney, Australia) and Cape Town University (South Africa). He then qualified with a First from the University of Frankfurt Medical School in 1997. He then worked in a number of Paediatric subspecialty departments at the Paediatric University Hospital of Frankfurt until 1999, when he moved to the UK. He subsequently worked in the Paediatric units of several renowned teaching hospitals in London, including King's College Hospital (Hepatology and Pediatric Intensive Care Unit), St. Mary's Hospital (Infectious Diseases) and Great Ormond Street Hospital for Children (Infectious Diseases, Immunology, Bone Marrow Transplant). In 2003/2004 he attended a MSc degree program in Molecular Biology of Infectious Diseases at the London School of Hygiene and Tropical Medicine, where he was awarded the Ralph Neal Memorial Prize for most outstanding student. In September 2004 he entered the North London Paediatric Specialist Registrar training program. In 2006/2007 he worked as a Specialist Registrar in Paediatric Infectious Diseases at St. Mary's Hospital in London. In 2007, supported by a prestigious Fellowship from the European Society for Paediatric Infectious Diseases and an International Research Scholarship from the University of Melbourne, he relocated to Australia to undertake his PhD at the University of Melbourne and the Royal Children’s Hospital Melbourne under the supervision of Professor Nigel Curtis. Following 4 years of research into improved immunodiagnostic tools for the diagnosis of childhood tuberculosis he returned to the UK in 2011 to take up his current position as NIHR Clinical Lecturer in Paediatric Infectious Diseases & Immunology at the University of Southampton.

研究领域

Marc Tebruegge’s main research interest is in the immunodiagnosis of human tuberculosis (TB). During his PhD studies he identified a number of promising immunological biomarkers of both latent and active TB, which are currently being validated in clinical studies in both adults and children. Past and present collaborations related to TB diagnostics include researchers based at a number of international institutions, including Tufts University Boston, the University of Cape Town, the University of New South Wales, the University of Papua New Guinea, the Victorian Infectious Diseases Reference Laboratories, the Murdoch Children’s Research Institute, and the University of Melbourne. In addition to his interest in TB, he has a strong interest in nontuberculous mycobacterial (NTM) infections, having recently completed a study on NTM disease in children in Australia. Furthermore, he has researched and published on a diverse range of infectious diseases and pathogens, including bacterial tracheitis, epiglottitis, sinusitis, urinary tract infections, meningitis, ureaplasma infections, enterovirus infections, adenovirus infections, influenza virus infections, varizella zoster infections, pneumococcal infections, and pediculosis capitis (head lice) infestation. He has also authored two chapters in the most recent edition of the RCPCH Manual of Childhood Infections (Pediculosis and Intra-abdominal infections), and co-authored two chapters in the most recent edition of the renowned reference textbook Principles & Practice of Pediatric Infectious Diseases (Nontuberculous mycobacterial infections and Infections related to the upper and middle airways). Since 2013 he is the Clinical Lead of a multi-center study funded by the U.K. Technology Strategy Board that involves a private/public partnership of investigators at University College London, the University of Edinburgh, the University of Glasgow and Epigem Ltd. The aim of this project (MIMIC - Multifunctional Integrated Microsystem for rapid point-of-care TB IdentifiCation) is to develop a rapid point-of-care test for the diagnosis of tuberculosis.

近期论文

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Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model - Tezera, Liku B., Bielecka, Magdalena K., Chancellor, Andrew, Reichmann, Michela T., Al Shammari, Basim, Brace, Patience, Batty, Alex, Tocheva, Anna, Jogai, Sanjay, Marshall, Ben G., Tebruegge, Marc, Jayasinghe, Suwan N., Mansour, Salah and Elkington, Paul T. Published:2017Publication:eLifePage Range:1-47doi:10.7554/eLife.21283 Tuberculosis: an infection-initiated autoimmune disease? - Elkington, Paul, Tebruegge, Marc and Mansour, Salah Published:2016Publication:Trends in ImmunologyPage Range:1-3doi:10.1016/j.it.2016.09.007PMID:27773684 European shortage of purified protein derivative and its impact on tuberculosis screening practices - Tebruegge, Marc, Buonsenso, Danilo, Brinkmann, Folke, Antoni , Noguera-Julian , Ivan , Pavić , Adriana , Sorete Arbore , Zuzana , Vančíková , Svetlana , Velizarova , Steven B , Welch and Nicole , Ritz Published:2016Publication:The International Journal of Tuberculosis and Lung DiseaseVolume:20, (10)Page Range:1293-1299doi:10.5588/ijtld.15.0975PMID:27725037 The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe – A Paediatric Tuberculosis Network European Trials Group (ptbnet) survey - Kontturi, Antti, Santiago, Begoña, Tebruegge, Marc, von Both , Ulrich, Salo, Eeva and Ritz, Nicole Published:2016Publication:TuberculosisVolume:101Page Range:125-129doi:10.1016/j.tube.2016.08.005 Comparable CD4 and CD8 T cell responses and cytokine release after at-birth and delayed BCG immunisation in infants born in Australia - Ritz, Nicole, Casalaz, Dan, Donath, Susan, Tebruegge, Marc, Dutta, Binita, Connell, Tom, Robins-Browne, Roy, Britton, Warwick, Hanekom, Willem and Curtis, Nigel Published:2016Publication:VaccineVolume:34, (35)Page Range:4132-4139doi:10.1016/j.vaccine.2016.06.077PMID:27396518