Swindle, Emily Jane - University of Southampton

个人简介

Dr Emily Swindle was appointed Lecturer in Pharmacology in the Faculty of Medicine, University of Southampton in February 2013. She gained her doctorate in Immunopharmacology from the University of Liverpool in 2003 under the supervision of Dr John Coleman studying the mechanisms of IgE-mediated mast cell (MC) activation. She then moved to the USA to undertake a postdoctoral fellowship at the National Institutes of Health under the supervision of Dr Dean Metcalfe to expand her studies of MC activation in allergic asthma and investigate MC responses to innate stimuli. While at NIH she received a Fellows Award for Research Excellence (FARE). On returning to the UK, she continued her interest in respiratory diseases undertaking research with Prof. Donna Davies on a multidisciplinary project investigating the interaction of bronchial epithelial cells (BEC) and dendritic cells in asthma using a novel microfluidic device to monitor the epithelial barrier by electrical impedance spectroscopy. This was in collaboration with Prof. Hywel Morgan (IfLS). In 2010, Emily was awarded a career track fellowship by the Faculty of Medicine to investigate the interaction of MCs with BECs in viral-induced exacerbations of asthma. Her current research focuses on building complex models of the airways incorporating structural cells and MCs to determine their role in viral-induced exacerbations of asthma.

研究领域

Dr Emily Swindle’s research focuses on building complex in vitro models of the airways incorporating structural cells and immune cells (including mast cells and dendritic cells) to determine their role in viral-induced exacerbations of asthma. She has an interdisciplinary approach to her research with close collaborations with Electronic and Computer Sciences, Engineering and Chemistry. There are 3 main areas of her research Interaction of Bronchial Epithelial Cells with innate immune cells: Bronchial epithelial cells form a physical, chemical and immunological barrier of the airways which restricts the free passage of solutes and particles from the external to the internal environment. My research is focused on understanding the complex interaction between epithelial cells and other resident structural cells of the airway including fibroblast and resident immune cells including mast cells (MCs) and dendritic cells (DCs) during rhinovirus infection in asthma. These models of the airway use differentiated primary bronchial epithelial cells (BECs), monocyte-derived DCs and MCs from cord blood as well as cell lines. This will allow the elucidation of the complex interactions between resident immune cells and structural cells of the airways in the context of asthma exacerbations. Understanding the role of mast cells in innate immunity: Mast cells are tissue-resident immune cells that are classically associated with the early phase reaction in allergic asthma. However, over the past 20 years there has been a growing realisation that mast cells are key drivers of innate immunity. Lying at the interface between the internal and external environment they sense pathogens and are key to the recruitment of inflammatory cells. While their role in bacterial induced immunity is established their role in viral immunity is not so clear. Current research is focused on elucidating the contribution of mast cells to respiratory virus infection including rhinovirus. An interdisciplinary approach to studying the epithelial barrier: Animal models of allergic asthma fail to recapitulate the complex interplay between genetic and environmental factors which together contribute to the human disease. In collaboration with Prof. Hywel Morgan, Prof. Donna Davies, Dr Jane Collins and Dr Tim Millar current research involves building a microfluidic device incorporating electrical impedance spectroscopy to monitor responses of the mucosal epithelial barrier to environmental stimuli. This device has greater sensitivity than static cultures and allows real-time monitoring of cellular responses to environmental stimuli. We are also using this device to look at endothelial and epithelial cell co-cultures to environmental stimuli which models the airway-blood barrier. Current research in Dr Swindle’s laboratory is kindly supported by NC3Rs, DSTL, The Allergy, Asthma & Inflammation Research (AAIR) charity and The Gerald Kerkut Charitable trus

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Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations - Akoto, Charlene, Davies, Donna E. and Swindle, Emily J. Published:2016Publication:Clinical & Experimental AllergyPage Range:1-31doi:10.1111/cea.12879PMID:28008678 Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA - Blume, Cornelia, Reale, Riccardo, Held, Marie, Loxham, Matthew, Millar, Tim, Collins, Jane, Swindle, Emily, Morgan, Hywel and Davies, Donna Published:2016Publication:Immunity, Inflammation and DiseasePage Range:1-34 Modulation of human airway barrier functions during Burkholderia thailandensis and Francisella tularensis infection - Blume, Cornelia, David, Jonathan, Bell, Rachel E., Laver, Jay R., Read, Robert C., Clark, Graeme C., Davies, Donna E. and Swindle, Emily Published:2016Publication:PathogensVolume:5, (53)Page Range:1-14doi:10.3390/pathogens5030053 IL-1alpha mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit - Hill, Alison R., Donaldson, Jess E., Blume, Cornelia, Smithers, Natalie, Tezera, Liku, Tariq, Kamran, Dennison, Patrick, Rupani, Hitasha, Edwards, Matthew J., Howarth, Peter H., Grainge, Chris, Davies, Donna E. and Swindle, Emily J. Published:2016Publication:Tissue BarriersVolume:4, (3)Page Range:1-12doi:10.1080/21688370.2016.1206378 Temporal monitoring of differentiated human airway epithelial cells using microfluidics - Blume, Cornelia, Reale, Riccardo, Held, Marie, Millar, Timothy M., Collins, Jane E., Davies, Donna E., Morgan, Hywel and Swindle, Emily J. Published:2015Publication:PLoS ONEVolume:10, (10)Page Range:1-13doi:10.1371/journal.pone.0139872PMID:26436734