Strefford, Jonathan - University of Southampton

个人简介

Professor Jonathan Strefford is a Professor in Cancer Molecular Genetics in the Faculty of Medicine at the University of Southampton. After two years NHS training in clinical cytogenetics, Jon started his postgraduate education with a Ph.D. in Cancer Genetics and Genetic Toxicology at the University of Wales, Swansea. In 2000, he started his postdoctoral careers, working with Professor Bryan Young at the Cancer Research UK Medical Oncology Laboratory at St Bartholomew’s Hospital, London. In 2002, he received a Lectureship from Queen Mary and Westfield College, University of London, prior to a move to the University of Southampton. In 2008, after four years working with Professor Christine Harrison, Jon was awarded a Personal Fellowship from Leukaemia and Lymphoma Research and a Senior Lectureship within the Faculty of Medicine. Jon currently has a research group working on the genetic analysis of chronic lymphocytic leukaemia (CLL) and splenic marginal zone lymphoma (SMZL). To facilitate these research objectives, Professor Strefford has attracted more than £4.5 million in grant funding from national and international research agencies and charities. He has spoken at international meetings such as the American Society of Hematology and the American Association for Cancer Research. Professor Strefford acts as an editorial board member for a number of international scientific journals, and on a number of national and international scientific committees.   Professor Strefford has extensive experience as a consultant for commercial companies, facilitating the development of FISH and microarray products. He also has strong links with the pharmaceutical industry and acts as a consultant and contract research provider for a series of large international clinical trials.

研究领域

Professor Strefford’s research has focused on the identification and characterization of genomic defects in cancer cells.  Genomic abnormalities are the hallmark of human cancer and can aid in appropriate patient management. The presence of these genomic alterations can have utility as Biomarkers by providing guidance on the most appropriate treatment regime and identify those patients likely to develop progressive disease or those that might exhibit limited response to treatment. The research projects coordinated by Professor Strefford include: Biomarker Discovery: Using whole genome analysis for copy number changes and sequence mutations to screen clinically-informative leukaemia and lymphoma cohorts. Biomarker Validation: Using target molecular and NGS technologies to determine the clinical impact of genomic lesions on the patient survival and response to treatment, particularly in the clinical trials context. Functional Analysis: Using in vitro and in vivo model systems we assess the role of novel genetic lesions in the pathophysiology of B-cell neoplams.

近期论文

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Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial - Strefford, Jon Published:2016Publication:Leukemia Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 - Garcia, Edwin, Hayden, Annette, Birts, Charles, Britton, Edward, Cowie, Andrew, Pickard, Karen, Mellone, Massimiliano, Choh, Clarisa, Derouet, Mathieu, Duriez, Patrick, Noble, Fergus, White, Michael J., Primrose, John, Strefford, Jonathan C., Rose-Zerilli, Matthew, Thomas, Gareth, Ang, Yeng, Sharrocks, Andrew D., Fitzgerald, Rebecca C. and Underwood, Timothy J. Published:2016Publication:Scientific reportsVolume:6, (32417)Page Range:1-12doi:10.1038/srep32417PMID:27600491 ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres - Narvrkalova, V., Young, E., Baliakas, P., Radova, L., Sutton, L.-A., Plevova, K., Mansouri, L., Ljungstrom, V., Ntoufa, S., Davis, Z., Juliusson, G., Smedby, K.E., Belessi, C., Panagiotidis, P., Touloumenidou, T., Davi, F., Langerak, A.W., Ghia, P., Strefford, J.C., Oscier, D., Mayer, J., Stamatopolous, K., Pospisolova, S., Rosenquist, R. and Trbusek, M. Published:2016Publication:HaematologicaVolume:101Page Range:e369-e373doi:10.3324/haematol.2016.142968PMID:27479817 Surface IgM expression and function associate with clinical behavior, genetic abnormalities and DNA methylation in CLL - D'Avola, Annalisa, Drennan, Samantha, Tracy, Ian, Henderson, Isla, Chiecchio, Laura, Larrayoz, Marta, Rose-Zerilli, Matthew, Strefford, Jonathan, Plass, Christoph, Johnson, Peter W., Steele, Andrew J., Packham, Graham, Stevenson, Freda K., Oakes, Christopher C. and Forconi, Francesco Published:2016Publication:BloodPage Range:1-25doi:10.1182/blood-2016-03-707786PMID:27301861