Staples, Karl - University of Southampton

个人简介

Dr Karl Staples is a Lecturer in Translational Medicine within the Faculty of Medicine. His research focuses on the role of the macrophage in chronic lung diseases, such as asthma and Chronic Obstructive Pulmonary Disease (COPD), and how the function of these cells can be changed by infection with common respiratory viruses like influenza. He is also an Enterprise Fellow for the Clinical & Experimental Sciences Academic Unit acting as an interface between the Unit and external partners.

研究领域

Dr Staples’ research interests lie squarely in the field of immunology, with a firm focus on airway macrophage function. His particular focus is on the role of macrophages in chronic inflammatory airways diseases, such as asthma and COPD, and their contribution to viral exacerbations of these conditions. The research is broadly split along the following lines: Understanding local protective immunity in the airway The overall aim of this GSK funded project is to enhance our understanding of the relevance of local immunity to protection of the airway from bacterial infections and thus development of vaccines against these organisms. The specific aims are: Quantify local protective immune response to different bacterial species Validate the methods for quantifying local immunity as tools for use in pre-clinical/clinical studies of vaccines Ex vivo modelling of viral infections In collaboration with Dr Tom Wilkinson, Dr Ben Nicholas and Prof Ratko Djukanovic, I have extended the use of the bronchial explant model by developing flow cytometric methods which enable - for the first time - quantification and characterisation of the function of all inflammatory and structural cells in the explant. This has resulted in a large programme to study respiratory viral infections ex vivo, particularly investigating susceptibility markers for infection in asthma and COPD. This platform has attracted ~£400k in funding from 3VBiosciences (Switzerland), a University of Zurich spin-out founded by Prof Ari Helenius. This grant has enabled us to further develop this model and test novel anti-viral (in particular, influenza) compounds provided by the company. The lung explant model as a means to study viral infections and anti-viral agents has been submitted to the UK Patent Office for protection (PCT/GB2010/050821 WO 2010/133881). Role of macrophages in influenza-induced pneumonia As an adjunct to the above two projects, I am studying the role of macrophages in influenza and specifically their role in pneumonia. Since influenza infection can predispose to bacterial as well as viral pneumonia, in collaboration with Dr Myron Christodoulides, I am investigating how macrophage anti-bacterial activity can be modulated by infection with influenza virus. This project has recently been extended to analyse the interaction of influenza-infected lung macrophages with T cells with the receipt of the HC Roscoe Award from the BMA.

近期论文

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Human lung fibroblasts present bacterial antigen to autologous lung T helper cells - Hutton, Andrew J., Polak, Marta E., Spalluto, C. Mirella, Wallington, Joshua C., Pickard, Christopher, Staples, Karl J., Warner, Jane A. and Wilkinson, Tom M.A. Published:2017Publication:The Journal of ImmunologyVolume:198, (1)Page Range:110-118doi:10.4049/jimmunol.1600602PMID:27895174 Relationships between mucosal antibodies, non-typeable haemophilus influenzae (NTHi) infection and airway inflammation in COPD - Staples, Karl J., Taylor, Stephen, Thomas, Steve, Leung, Stephanie, Cox, Karen, Pascal, Thierry G., Ostridge, Kristoffer, Welch, Lindsay, Tuck, Andrew C, Clarke, Stuart C, Gorringe, Andrew and Wilkinson, Thomas Published:2016Publication:PLoS ONEPage Range:1-17doi:10.1371/journal.pone.0167250PMID:27898728 Seasonality, risk-factors and burden of community-acquired pneumonia in COPD patients: A population database study using linked healthcare records - Williams, Nicholas P, Coombs, Ngaire A, Johnson, Matthew, Josephs, Lynn, Rigge, Lucy, Staples, Karl J., Thomas, Mike and Wilkinson, Tom M A Published:2016Publication:International Journal of Chronic Obstructive Pulmonary DiseasePage Range:1-23 Therapeutics for acute lung injury: time to call in the DRs? - Staples, Karl J. Published:2016Publication:Journal of Leukocyte BiologyPage Range:1-14 Editorial. Lung macrophages: old hands required rather than new blood? - Staples, Karl J. Published:2016Publication:ThoraxVolume:71, (11)Page Range:973-974doi:10.1136/thoraxjnl-2016-208992PMID:27531530