Smith, David - University of Southampton

个人简介

Dr Smith was appointed as Senior Lecturer in Anaesthesia in 1992. After graduation from the University of Nottingham, he trained in anaesthesia in Nottingham, London, Plymouth, and Bristol before being appointed as Consultant in cardiac anaesthesia in Glasgow in 1990. He completed his DM on electromyographic monitoring of muscle function during anaesthesia in 1996. Dr Smith provides a clinical link for three different research groups within the University of Southampton; the Institute of Sound and Vibration Research (Prof R Allen and Dr S Bell), the vascular biology group (Prof G Clough, Dr N Englyst), and the molecular biology group (Prof P Townsend). Dr Smith is Consultant in adult and paediatric cardiac anaesthesia, and adult cardiac intensive care, at Southampton General Hospital.

研究领域

Dr Smith’s research interests are in monitoring of the anaesthetic state during surgery, and perioperative care for the cardiac surgical patient. Monitoring anaesthesia Evaulation of EEG-based techniques for assessing cerebral activity during anaesthesia and development of methodology to enable faster, more reliable, data acquisition during surgery. This work is a collaboration with Prof Robert Allen and Dr Steven Bell in the Institute of Sound and Vibration Research. Microparticle activity during cardiac surgery In collaboration with the vascular biology group (Prof Geraldine Clough, Dr Nicola Englyst), this project explores the role of platelet and endothelial microparticles in coagulation during cardiac surgery. Anaesthetic preconditioning This project, in collaboration with Prof Paul Townsend, examines the cellular mechanisms of myocardial protection by volatile anaesthetic agents during the ischaemic phase of cardiac surgery.

近期论文

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A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers - Hanley, Christopher J., Noble, Fergus, Ward, Matthew, Bullock, Marc, Drifka, Cole, Mellone, Massimiliano, Manousopoulou, Antigoni, Johnston, Harvey E., Hayden, Annette, Thirdborough, Stephen, Liu, Yuming, Smith, David M., Mellows, Toby, Kao, W. John, Garbis, Spiros D., Mirnezami, Alexander, Underwood, Tim J., Eliceiri, Kevin W and Thomas, Gareth J. Published:2015Publication:OncotargetVolume:7, (5)Page Range:6159-6174doi:10.18632/oncotarget.6740PMID:26716418 Auditory evoked potentials for monitoring during anaesthesia: a study of data quality - Notley, S.V., Bell, S.L. and Smith, D.C. Published:2010Publication:Medical Engineering and PhysicsVolume:32, (2)Page Range:168-173doi:10.1016/j.medengphy.2009.11.006 The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction - Smith, M.N.A., Best, D., Sheppard, S.V. and Smith, D.C. Published:2008Publication:AnaesthesiaVolume:63, (7)Page Range:701-704doi:10.1111/j.1365-2044.2007.05408.x The effect of mannitol on renal function following cardio-pulmonary bypass in patients with normal pre-operative creatinine - Yallop, K.G., Sheppard, S.V. and Smith, D.C. Published:2008Publication:AnaesthesiaVolume:63, (6)Page Range:576-582doi:10.1111/j.1365-2044.2008.05540.x The influence of mannitol on the volume of fluid given to adult patients during cardiopulmonary bypass - Mo, Y., Sheppard, S.V. and Smith, D.C. Published:2007Publication:AnaesthesiaVolume:62, (11)Page Range:p.1193doi:10.1111/j.1365-2044.2007.05344.x