Sanchez-Elsner, Tilman - University of Southampton

个人简介

Tilman Sanchez-Elsner studied Biology at the Universidad Complutense of Madrid, Spain, pursuing the PhD in the same University at the Department of Biochemistry and Molecular Biology (June 2002). The actual research thesis work was carried out under the supervision of Dr Carmelo Bernabeu and Luisa M. Botella, in the Centro de Investigaciones Biologicas (Madrid), belonging to the Spanish Research Council. During his PhD, Tilman focused on the transcriptional control of angiogenesis and repair in human, describing the co-operation between two transcription factors, HIF-1a (Hypoxia Inducible Factor) and Smad3 (which mediates TGF-a inducible responses). After his PhD, and being interested in a more global kind of regulation of transcription, he then moved into the field of epigenetics. He was a postdoctoral fellow (2002-2006) at the University of California at Riverside, working with Dr Frank Sauer. Here, he described a novel non-coding RNA, crucial for the epigenetic control of the fruit fly development. As a result of the work with non-coding RNAs and the contact with expert groups in the field (Dr. Sowei Ding, Dr Juan Diaz-Pendon), he became interested in the field of MicroRNAs. He was then interested in applying the acquired knowledge to the human model, and more specifically, to work in Immunology and hematopoietic development. He started working in the field of microRNAs since 2006, in the lab of Dr A.L. Corbi, as a senior postdoc. In this lab, he acquired expertise in the immunological techniques, as well as in the field of MicroRNAs. Finally, he decided to develop his own independent research. His goal was to liaise to the clinical world, in order to apply the acquired knowledge to understand the molecular basis of clinical issues. For this reason, he joined the University of Southampton, as a Lecturer in Biomedical Sciences of the Division of Infection, Inflammation and Repair (School of Medicine) in August 2007. He is currently engaged in several projects related to microRNA expression and function.

研究领域

MicroRNAs in Disease We are interested in the role of microRNAs in disease. There have been recent advances in the field, pointing out an important role for these small non-coding RNAs during development and in disease. Together with several of the researchers of the School of Medicine, we are trying to determine the involvement of certain MicroRNAs in pathologies that implicate an imbalance in the immune response (in lung, skin, kidney, gut). We have already shown that miR-155, a pro-inflammatory microRNA, inhibits the IL13 and TGF-beta pathways and reduces pathogen binding by dendritic cells. These are important aspects in diseases like asthma and Inflammatory Bowel disease and therefore we are currently working on the dysregulation of this microRNA and others in these pathologies. We believe that understanding the network of microRNAs affecting a disease will help design future targeted therapies. Cross-disciplinary research As a result of an interdisciplinary collaboration with Dr Antonios Kanaras (School of Physics and Astronomy), we have developed different strategies involving the use of functionalised nanoparticles to answer current molecular biology and clinical challenges. As part of the cross-disciplinary interest of the group we have generated interesting results in the transfection of cell using sonic waves with a sonoporation chamber. Also, we have designed and developed a microfluidic chamber that allows us to monitor, in real time, the interaction of immune cells (dendritic cells and macrophages, so far) with pathogens. We expect this field to be a useful and general tool for medical and research applications in the future.

近期论文

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Modulation of nonsense mediated decay by rapamycin - Martinez-Nunez, Rocio, Wallace, Andrew, Coyne, Doyle, Jansson, Linnea, Rush, Miles, Ennajdaoui, Hanane, Katzman, Sol, Bailey, Joanne Louise, Deinhardt, Katrin, Sanchez-Elsner, Tilman and Sanford, Jeremy R. Published:2016Publication:Nucleic Acids ResearchPage Range:1-12doi:10.1093/nar/gkw1109PMID:27899591 Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors - Wood, Oliver, Woo, Jeongmin, Seumois, Gregory, Savelyeva, Natalia, Mccann, Katy J., Singh, Divya, Jones, Terry, Peel, Lailah, Breen, Michael S, Ward, Matthew, Garrido Martin, Eva, Sanchez-Elsner, Tilman, Thomas, Gareth, Vijayanand, Pandurangan, Woelk, Christopher H., King, Emma and Ottensmeier, Christian Published:2016Publication:OncotargetPage Range:1-17doi:10.18632/oncotarget.10788PMID:27462861 Toll-like receptor 7 is reduced in severe asthma and linked to altered microRNA profile - Sanchez-Elsner, Tilman, Rupani, Hitasha, Howarth, Peter, Lau, Laurie, Martinez-Nunez, Rocio Teresa, Havelock, Tom, Grainge, Chris, Francisco-Garcia, Ana, Jayasekera, Nivenka and Dennison, Patrick Published:2016Publication:American Journal of Respiratory and Critical Care Medicinedoi:10.1164/rccm.201502-0280OCPMID:26815632 Identification of host miRNAs that may limit human rhinovirus replication - Bondanese, Victor Paky, Francisco-Garcia, Ana, Bedke, Nicole, Davies, Donna E and Sanchez-Elsner, Tilman Published:2014Publication:World Journal of Biological ChemistryVolume:5, (4)Page Range:437-456doi:10.4331/wjbc.v5.i4.437PMID:25426267