Sampson, Anthony - University of Southampton

个人简介

Tony Sampson has a first degree in natural sciences from the University of Cambridge and a PhD in pharmacology from King's College London. After two years at the Royal Postgraduate Medical School in London, in 1985 he joined the pharmacology department at the Royal College of Surgeons of England, a group known for its work on lipid mediators, including the discovery of thromboxane and leukotriene structures, and the Nobel-winning discovery of the mechanism of aspirin. As the Frances & Augustus Newman Foundation Lecturer in 1990, he collaborated with the Thoracic Unit at King's College School of Medicine to study the biology of leukotrienes in respiratory diseases including asthma, cystic fibrosis, bronchiolitis and chronic lung disease of infancy. In 1995, he relocated to the world-leading asthma research group of Professor Stephen Holgate at Southampton. His leukotriene research has received significant charitable and commercial funding and he collaborates extensively with other lipid mediator groups, leading to the publication of more than 100 papers, editorials, reviews and book chapters and to more than 40 invited lectures at national and international conferences. He succeeded Professor Holgate as director of the respiratory group in 2002, and led the formation of the Allergy & Inflammation Research (AIR) subdivision and its co-location of adult and paediatric asthma research into refurbished laboratories in the Sir Henry Wellcome Building. Since 2006 Dr Sampson has been head of the Clinical Pharmacology & Therapeutics, the most highly-evaluated subject in the medical school, and since 2011 has led Year 1 of the BM5/BM6/BM(EU) programme. He is the education lead for CES Academic Unit, and an editorial board member of various pharmacology journals, a Trustee of the AAIR Charity and a Fellow of the Higher Education Academy. In 2011 he won the Vice-Chancellor’s Teaching Award and in 2012 and again in 2013 he was voted ‘Outstanding Lecturer’ in the Faculty of Medicine by Southampton students. He is the co-author of Medical Pharmacology & Therapeutics (Elsevier, 2014).

研究领域

The classical familes of lipid mediators (eicosanoids including leukotrienes, prostaglandins, and thromboxanes) have roles in asthma, inflammation, auto-immune disease, pain, haemostasis and other important biological processes relevant to human disease. Drugs which modulate these lipids, including the non-steroidal anti-inflammatory drugs (NSAIDs) and the leukotriene modifiers (lukasts) are among the world’s best sellers, being variously used as painkillers, anti-pyretics, anti-inflammatories, bronchodilators and anti-platelet drugs. There is much research also into possible roles of lipid mediators in atherogenesis, carcinogenesis and neural injury. In addition, new families of non-classical or anti-inflammatory lipids, including lipoxins, resolvins and protectins, have attracted interest as potential immunodulatory agents. Our research aims to explore the roles of eicosanoids and related lipid mediators in inflammatory diseases to support the development of novel therapies and optimise the use of existing drugs.

近期论文

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MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice - Hawkes, Cheryl A., Shaw, James E., Brown, Mary, Sampson, Anthony P., McLaurin, JoAnne and Carare, Roxana O. Published:2013Publication:Neurodegenerative DiseasesPage Range:1-7doi:10.1159/000351096 MK886 reduces cerebral amyloid angiopathy severity in the TgCRND8 mouse model of Alzheimer’s disease - Hawkes, C.A., Shaw, J.E., Brown, M., Sampson, A.P., McLaurin, J. and Carare, Roxana O. Published:2013Publication:Neurodegenerative Diseases Activity of the leukotriene pathway in Barrett’s metaplasia and oesophageal adenocarcinoma - Shutt, James David, Boger, Philip, Neale, James Richard, Patel, Praful and Sampson, Anthony Peter Published:2012Publication:Inflammation ResearchVolume:61, (12)Page Range:1379-1384doi:10.1007/s00011-012-0539-2PMID:22851204 Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy - Arshad, S.H., Dharmage, S.C., Ferreira, F., Fixman, E.D., Gadermaier, G., Hauser, M., Sampson, A.P., Teran, L.M., Wallner, M. and Wardlaw, A.J. Published:2012Publication:Clinical and Experimental AllergyVolume:42, (12)Page Range:1697-1723doi:10.1111/cea.12037PMID:23181787 Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma - Boger, Philip C., Shutt, James D., Neale, James R., Wilson, Susan J., Bateman, Adrian C., Holloway, John W., Patel, Praful and Sampson, Anthony P. Published:2012Publication:HistopathologyVolume:61, (3)Page Range:509-517doi:10.1111/j.1365-2559.2012.04258.x