个人简介
As a cancer geneticist, my research elucidates the natural history of a patient’s cancer at the DNA level with the aim of providing improved clinical prognoses. As Faculty of Medicine Career Track Fellow, I am exploring the power of single-cell analyses to understand more about the evolution of blood cancer and the interaction between different mutations in individual cancer cells.
Dr. Matthew Rose-Zerilli graduated from the University of Portsmouth in 2002. He went on to work in the Pharmacogenomics industry at Sciona Inc. as a Research & Development Scientist. In 2003, Matthew returned to academia in Southampton as a research assistant in the Human Genetics Division, Faculty of Medicine.
Following his PhD in the Respiratory Genetics Laboratory of Professor John Holloway, Matthew joined the Cancer Genomics laboratory of Professor Jonathan Strefford within the Cancer Sciences Unit in the Faculty of Medicine as a postdoctoral researcher. After two successful postdoctoral positions and through mentorship from Professor Strefford, he is now developing his own research area in cancer genetics.
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Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 - Garcia, Edwin, Hayden, Annette, Birts, Charles, Britton, Edward, Cowie, Andrew, Pickard, Karen, Mellone, Massimiliano, Choh, Clarisa, Derouet, Mathieu, Duriez, Patrick, Noble, Fergus, White, Michael J., Primrose, John, Strefford, Jonathan C., Rose-Zerilli, Matthew, Thomas, Gareth, Ang, Yeng, Sharrocks, Andrew D., Fitzgerald, Rebecca C. and Underwood, Timothy J. Published:2016Publication:Scientific reportsVolume:6, (32417)Page Range:1-12doi:10.1038/srep32417PMID:27600491
Surface IgM expression and function associate with clinical behavior, genetic abnormalities and DNA methylation in CLL - D'Avola, Annalisa, Drennan, Samantha, Tracy, Ian, Henderson, Isla, Chiecchio, Laura, Larrayoz, Marta, Rose-Zerilli, Matthew, Strefford, Jonathan, Plass, Christoph, Johnson, Peter W., Steele, Andrew J., Packham, Graham, Stevenson, Freda K., Oakes, Christopher C. and Forconi, Francesco Published:2016Publication:BloodPage Range:1-25doi:10.1182/blood-2016-03-707786PMID:27301861
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukemia - Parker, Helen, Rose-Zerilli, Matthew J.J., Larrayoz, Marta, Clifford, Ruth, Edelmann, Jennifer, Blakemore, Stuart, Gibson, Jane, Wang, Jun, Ljungstrom, Viktor, Wojdacz, Tomasz K., Chaplin, Tracy, Roghanian, Ali, Davis, Zadie, Parker, Anton, Tausch, Eugen, Ntoufa, Stavroula, Ramos, Sara, Robbe, Pauline, Alsolami, Reem, Steele, Andrew J., Packham, Graham, Rodriquez-Vicente, Ana E., Brown, Lee, McNicholl, Feargal, Forconi, Francesco, Pettitt, Andrew, Hillmen, Peter, Dyer, Martin, Cragg, Mark S., Chelala, Claude, Oakes, Christopher C., Rosenquist, Richard, Stamatopoulos, Kostas, Stilgenbauer, Stephan, Knight, Samantha, Schuh, Anna, Oscier, David G. and Strefford, Jonathan C. Published:2016Publication:LeukemiaPage Range:1-22
The outcome of chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98% identity - Davis, Zadie, Forconi, Francesco, Parker, Anton, Gardiner, Anne, Thomas, Peter, Catovsky, Daniel, Rose-Zerilli, Matthew, Strefford, Jonathan and Oscier, David Published:2016Publication:British Journal of HaematologyPage Range:1-10doi:10.1111/bjh.13940PMID:26846718