Robinson, Siân - University of Southampton

个人简介

Professor Siân Robinson is Professor of Nutritional Epidemiology within Medicine at the University of Southampton. Siân completed a BSc in Nutrition and a PhD, at Queen Elizabeth College, University of London. Her first postdoctoral posts were in Southampton and Switzerland, in which she carried out clinical studies to determine influences on energy balance. She returned to Southampton in 1988 to join the MRC Lifecourse Epidemiology Unit (then Environmental Epidemiology Unit), where she has been responsible for the nutritional components of their large UK cohort studies. Her research addresses how variations in nutrition across the lifecourse contribute to inequalities in adult health, with a particular focus on early life influences on growth and development, and effects on ageing. Siân is a registered Nutritionist.

研究领域

To address how variations in nutrition across the lifecourse contribute to inequalities in adult health, Siân’s current research has three main themes. Assessing the diets of populations One of the greatest challenges in assessment of diet in large-scale cohort studies is to find appropriate and accessible methods to enable collection of accurate data across the population. Over the past decade, around 50,000 dietary assessments have been carried out by staff at the MRC Lifecourse Epidemiology Unit, within the main UK cohort studies, including the Southampton Women’s Survey (http://www.mrc.soton.ac.uk/index.asp?page=229) and the Hertfordshire Cohort Study (http://www.mrc.soton.ac.uk/index.asp?page=3). Both traditional approaches have been used as well as novel methods, developed for these studies. One of Siân’s continuing research interests is in methodological developments to enable characterization of diet in general population studies, with a particular focus on design of new methods that are widely accessible. Early life influences on body composition The dramatic increase in rates of childhood obesity has led to widespread research efforts to identify its causes, including understanding the role of ‘obesogenic’ environments, and the importance of unhealthy dietary behaviours and patterns of physical activity. However, despite the importance of these factors in contributing to gains in adiposity, not all children within a population become overweight. We need to know more about how individuals vary in the way that they interact with their environments, and the extent to which these interactions predispose some children to gain excess weight. Early life is recognised as a ‘critical period’ when the risk of development and persistence of overweight and obesity may be increased. Using children’s data from the Southampton Women’s Survey (http://www.mrc.soton.ac.uk/index.asp?page=229), we are describing the evolution of body composition in early life, and examining how variations in diet in infancy and early childhood, and maternal nutritional status in pregnancy, impact on child’s adiposity. Understanding the role of early nutrition will be key to developing future strategies to prevent obesity. Nutrition and ageing A significant challenge faced by ageing populations is how to enable older adults to remain independent and to maintain their quality of life. Central to independence is physical capability – ie the ability to perform the physical tasks of everyday living. Although declining physical capability in later life is expected, in parallel with age-related losses of muscle mass and strength, the rate of decline is not spread evenly across the population, and much of the variance remains unexplained. There is increasing interest in variations in diet and nutritional status among older adults, and their links to differences in muscle strength, walking disability and physical function. A number of nutritional intervention studies show beneficial effects on physical function, although findings are not always consistent, and the underpinning mechanisms remain poorly understood. Siân’s current research aims to address the contributions made by diet and lifestyle to declining physical capability, with a view to defining sustainable dietary interventions to slow losses of muscle mass and strength in older age.

近期论文

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Determinants of the maternal 25-hydroxyvitamin D response to vitamin D supplementation during pregnancy - Moon, R.J., Harvey, N.C., Cooper, C., D'angelo, S., Crozier, S.R., Inskip, H.M., Schoenmakers, I., Prentice, A., Arden, N.K., Bishop, N.J., Carr, A., Dennison, E.M., Eastell, R., Fraser, R., Gandhi, S.V., Godfrey, K.M., Kennedy, S., Zulf Mughal, M., Papageorghiou, A.T., Reid, D.M., Robinson, S.M and Javaid, M.K. Published:2016Publication:Journal of Clinical Endocrinology & MetabolismPage Range:5012-5020doi:10.1210/jc.2016-2869PMID:27788053 Influences on diet quality in older age: the importance of social factors - Bloom, Ilse, Edwards, Mark, Jameson, Karen, Syddall, Holly, Dennison, Elaine, Gale, Catharine, Baird, Janis, Cooper, Cyrus, Aihie Sayer, Avan and Robinson, Sian Published:2016Publication:Age and AgeingPage Range:1-17doi:10.1093/ageing/afw180PMID:27744301 Nausea and vomiting in early pregnancy: effects on food intake and diet quality - Crozier, Sarah, Inskip, Hazel, Godfrey, Keith, Cooper, Cyrus and Robinson, Sian Published:2016Publication:Maternal and Child NutritionPage Range:1-24 Maternal serum retinol and B-carotene concentrations and neonatal bone mineralisation: Results from the Southampton Women's Survey cohort - Handel, Mina N., Moon, Rebecca J., Titcombe, Philip, Abrahamsen, Bo, Heitmann, Berit L., Calder, Philip C., Dennison, Elaine M., Robinson, Sian M., Godfrey, Keith M., Inskip, Hazel M., Cooper, Cyrus and Harvey, Nicholas C. Published:2016Publication:American Journal of Clinical NutritionPage Range:1-24doi:10.3945/?ajcn.116.130146