Riethmacher, Dieter - University of Southampton

个人简介

Dr Dieter Riethmacher is Associate Professor in Human Genetics within Medicine at the University of Southampton. Dieter was appointed as a Reader in Human Genetics in 2007. Dieter has studied biology in Cologne and completed his Diploma thesis about expression and characterisation of c- and v-mos oncogenes in 1991. He then did his PhD in the Max-Delbrück Laboratory in Cologne working on the molecular regulation of adhesion and proliferation in epithelia using mouse models and cell biology. After completion in 1994 he moved to the Max-Delbrück-Center in Berlin where he continued to work with mouse models to analyse gene function. In 1999 Dieter was appointed as an independent group leader in the Centre for Molecular Neurobiology in Hamburg. During this time he initially focussed on glial development. He then developed a universal mouse model enabling to analyse cellular functions in complex organs or circuits. He also habilitated in Neurobiology in 2005 at the Faculty of Medicine, University of Hamburg. Currently Dieter leads a group that is interested in the analysis of cellular function in development, regeneration and disease. His lab is located in the Duthie Building on the Faculty of Medicine Campus. Dieter has several fruitful collaborations locally and abroad involving mouse models to analyse development and disease.

研究领域

GCIP in tumour development GCIP is involved in cell cycle progression and is localized on the human chromosome 15q15, a locus harbouring a tumour suppressor gene. Our knock-out model enables us to analyse the postulated modulatory role of GCIP during cell cycle progression and also to unravel its role for tumour formation and progression. Molecules in peripheral nerve regeneration Taking advantage of a recently developed femoral nerve injury paradigm allowing precise evaluation of motor recovery and subsequent morphological evaluation of nerve regeneration in the same animals we compare functional recovery in adult mice that are mutant for specific genes that are thought to be important for regeneration. We have a special interest in molecules of the extracellular matrix (ECM). Analysis of cellular functions Loss of cells has a great impact on the whole organism not only during development but also for homeostasis, senescence and for pathogenesis. The specific ablation of cells in an otherwise intact, unaffected organism would make it possible to analyse cellular functions. Therefore, we have developed a novel strain of mice enabling us to specifically ablate any celltype (see also Fig. 1). The principle of this ablation mouse is the ubiquitous expression of a silenced toxin, which can be genetically activated in the offspring following mating with a recombinase expressing strain. The activation of the toxin may just be tissue-specific or additionally depending on agonist activation (e.g. tamoxifen).

近期论文

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Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice - Dahlhoff, Maik, Camera, Emanuela, Schäfer, Matthias, Emrich, Daniela, Riethmacher, Dieter, Foster, April, Paus, Ralf and Schneider, Marlon R. Published:2016Publication:DevelopmentVolume:143, (10)Page Range:1823-1831doi:10.1242/dev.132753 Stress-induced anxiety- and depressive-like phenotype associated with transient reduction in neurogenesis in adult Nestin-CreERT2/diphtheria toxin fragment A transgenic mice - Yun, Sanghee, Donovan, Michael H., Ross, Michele N., Richardson, Devon R., Reister, Robin, Farnbauch, Laure A., Fischer, Stephanie J., Riethmacher, Dieter, Gershenfeld, Howard K., Lagace, Diane C. and Eisch, Amelia J. Published:2016Publication:PLoS ONEVolume:11, (1)Page Range:e0147256doi:10.1371/journal.pone.014725PMID:26795203 Promotion of periostin expression contributes to the migration of Schwann cells - Sonnenberg-Riethmacher, E., Miehe, M. and Riethmacher, D. Published:2015Publication:Journal of Cell ScienceVolume:128, (17)Page Range:3345-3355doi:10.1242/jcs.174177 Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis - Rebourcet, Diane, O’Shaughnessy, Peter J., Pitetti, Jean-Luc, Monteiro, Ana, O’Hara, Laura, Milne, Laura, Tsai, Ji Ting, Cruickshanks, Lindsey, Riethmacher, Dieter, Guillou, Florian, Mitchell, Rod T., van ’t Hof, Rob, Freeman, Tom C., Nef, Serge and Smith, Lee B. Published:2013Publication:Development Volume:141, (10)doi:10.1242/dev.107029PMID:24803659 Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature NF-?B activation - Freimuth, Julia, Bangen, Jörg-Martin, Lambertz, Daniela, Hu, Wei, Nevzorova, Yulia Alexandrovna, Sonntag, Roland, Gassler, Nikolaus, Riethmacher, Dieter, Trautwein, Christian and Liedtke, Christian Published:2013Publication:HepatologyVolume:58, (5)Page Range:1779-1789doi:10.1002/hep.26538