Read, Robert Charles - University of Southampton

个人简介

Professor Robert Charles Read is Head of Academic Unit - Clinical and Experimental Sciences within Medicine at the University of Southampton. Professor Robert Read undertook clinical and research training in Sheffield, Leeds, Bristol, London, Nottingham and San Francisco. He was appointed as an academic infectious disease physician at the University of Sheffield in 1995 and served as Professor of Infectious Diseases there from 2002-2012, prior to moving to Southampton in September 2012. Professor Read has research interests in the pathogenesis and prevention of rapidly lethal infectious diseases, especially meningococcal and pneumococcal disease, and influenza. He is the chairman of the Infectious Diseases and Microbiology Specialty Group for the NIHR clinical research network, and Chairs the postdoctoral awards panel for the NIHR Personal Training Fellowships scheme. He was chairman of the 2013 Annual Meeting Program Committee of the Infectious Disease Society of America. He was appointed as member of the Joint Committee on Vaccine Implementation (JCVI) in September 2013. He is Editor in Chief of the Journal of Infection and Current Opinion in Infectious Diseases, and is author and co-author of 200 publications mainly in the field of infectious diseases.

研究领域

Read and colleagues conduct research to investigate pathogenesis, treatment and prevention of rapidly lethal infections; notably meningococcal disease and influenza. Successful colonisation of the mucosa of the upper respiratory tract is a prerequisite for disease and transmission of pathogens between human hosts. The focus of Reads group is on host and microbial factors that permit colonisation and disease. A number of models have been developed including human tissue and cell culture systems as well as human controlled infection to enable this. Human primary macrophages and respiratory mucosa are used to understand molecular pathogenesis Figure 1 Bacterial pathogenesis is investigated using defined mutations to determine the effect of individual bacterial elements on processing by host phagocytes and epithelial cells. Hitherto this has been done in cell culture systems including human monocyte-derived primary macrophages. Recent work has focussed on the use of controlled human infections, notably with Neisseria lactamica to determine how this organism interferes with colonisation and invasion by the pathogen Neisseria meningitidis. Human controlled infections are used to investigate natural colonisation and immunity Figure 2 Read has conducted a number of important (investigator-initiated) clinical observational studies and clinical trials. Some of these have been national and international networked studies including those which use the UK NIHR Clinical Research Network and its sub group for Infectious Disease and Clinical Microbiology, which Read chairs. Important work has included original studies on the effects of vaccination with sub capsular Neisseria meningitidis vaccines on microbial colonisation, and observational studies of influenza and its prevention.

近期论文

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Modulation of human airway barrier functions during Burkholderia thailandensis and Francisella tularensis infection - Blume, Cornelia, David, Jonathan, Bell, Rachel E., Laver, Jay R., Read, Robert C., Clark, Graeme C., Davies, Donna E. and Swindle, Emily Published:2016Publication:PathogensVolume:5, (53)Page Range:1-14doi:10.3390/pathogens5030053 Neisseria meningitidis serogroup B bivalent factor H binding protein vaccine - Brendish, Nathan J and Read, Robert C Published:2015Publication:Expert Review of VaccinesVolume:14, (4)Page Range:493-503doi:10.1586/14760584.2015.1015997PMID: 25703792 Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial - Read, Robert C., Baxter, D., Chadwick, D.R, Faust, S.N., Finn , A., Gordon, S.B., Heath, P.T., Lewis, D.J., Pollard, A.J., Turner, D.P., Bazaz, R., Ganguli, A., Havelock, T., Neal, K.R., Okike, I.O., Morales-Aza, B., Patel, K., Snape, M.D., Williams, J., Gilchrist, S., Maiden, M.C., Toneatto, D., Wang, H., McCarthy, M., Dull, P.M. and Borrow, R. Published:2014Publication:The Lancetdoi:10.1016/S0140-6736(14)60842-4PMID:25145775 An evaluation of community assessment tools (CATs) in predicting use of clinical interventions and severe outcomes during the A(H1N1)pdm09 pandemic - Cowling, Benjamin J., Semple, Malcolm G., Myles, Puja R., Nicholson, Karl G., Lim, Wei Shen, Read, Robert C., Taylor, Bruce L., Brett, Stephen J., Openshaw, Peter J.M., Enstone, Joanne E., McMenamin, James, Bannister, Barbara and Nguyen-Van-Tam, Jonathan S. Published:2013Publication:PLoS ONEVolume:8, (9)Page Range:e75384doi:10.1371/journal.pone.0075384PMID:24069409