Pringle, Ashley - University of Southampton

个人简介

Dr Ashley Pringle is Senior Lecturer within Medicine at the University of Southampton. Dr Pringle has been a Senior Lecturer in the Faculty of Medicine since 2005. He has a pharmacology degree from the University of Portsmouth. Subsequently, he obtained a PHD in neuropharmacology from the University of Southampton studying the electrophysiological properties of benzodiazepine ligands in the cerebellum. Since 1993 he has worked as a research fellow and academic in the Clinical Neurosciences group in the Faculty of Medicine at Southampton. Dr Pringle’s research interests focus on the role played by endogenous mediators such as cytokines and neurotrophins in response to acute brain injury. His research is centred around the use of in vitro models, and he is interested in developing novel tissue culture methods to study neurodegeneration. Dr Pringle has an active interest in the career development and training of postgraduate and postdoctoral researchers.

研究领域

Dr Pringle’s research focuses on acute neurodegenerative conditions such as stroke and traumatic brain injury (TBI). Both of these conditions have high rates of mortality and long-term morbidity but treatment options are currently limited. Developing a better understanding of the molecular mechanisms involved in the neurodegenerative processes should allow the development of more effective treatments for the future.

近期论文

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An interactive cranial nerve package for head and neck anatomy: bridging the gap between lecture and the lab - Border, S., Pringle, A. and , Published:2014Publication:Journal of AnatomyVolume:224, (6)Page Range:750doi:10.1111/joa.12175 Interleukin-1beta does not affect the energy metabolism of rat organotypic hippocampal-slice cultures - Saggu, Raman, Morrison, Barclay, Lowe, John P. and Pringle, Ashley K. Published:2011Publication:Neuroscience LettersVolume:508, (2)Page Range:114-118doi:10.1016/j.neulet.2011.12.032PMID:22215116 Transcriptomics of Traumatic Brain Injury: Gene Expression and Molecular Pathways of Different Grades of Insult in a Rat Organotypic Hippocampal Culture Model - Di Pietro, Valentina, Amin, Daven, Pernagallo, Salvatore, Lazzarino, Giuseppe, Tavazzi, Barbara, Vagnozzi, Roberto, Pringle, Ashley and Belli, Antonio Published:2010Publication:Journal of NeurotraumaVolume:27, (2)Page Range:349-359doi:10.1089/neu.2009.1095 The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC(2) receptors, or directs them towards a neuronal fate via VPAC(1) receptors. - Zaben, Malik, Sheward, W. John, Shtaya, Anan, Abbosh, Christopher, Harmar, Anthony J., Pringle, Ashley K. and Gray, William P. Published:2009Publication:Stem CellsVolume:27, (10)Page Range:2539-2551doi:10.1002/stem.184 Kainate enhances hippocampal precursor cell proliferation and survival in vitro, while Kainate induced seizures additionally recruits quiescent progenitors in vivo - Shtaya, A., Pringle, A. and Gray, W.P. Published:2008Publication:Federation of European Neuroscience Societies (FENS)Volume:4, (009.24)