Polak, Marta Ewa - University of Southampton

个人简介

Dr Marta Ewa Polak leads a Systems Immunology Group in Medicine at the University of Southampton. Marta E Polak trained in biotechnology at the Jagiellonian University, Krakow, Poland and graduated obtaining MSc degree in molecular biology. During her post-graduate project under the supervision of Prof Ian Cree and Dr Martine Jager she investigated the role of dendritic cells (DCs) in melanoma, and obtained the PhD in medicine at the University of Leiden, The Netherlands. In 2008 she moved to Southampton and joined Dr Michael Ardern-Jones in the newly formed Innate Immunity Group, in a project exploring the mechanisms of regulation of immune responses in human skin. In July 2012, she was awarded the Faculty of Medicine Career Track Award to investigate molecular mechanisms regulation the function of human dendritic cells. She has now received a prestigious Sir Henry Dale Fellowship from Wellcome Trust, for a project which combines immunological, signalling and bioinformatic investigational approaches as a means to fundamentally understand the mechanisms of immune regulation in human skin.

研究领域

Dr Polak’s research interest is focused on the mechanisms of regulation of immune responses by human tissue resident dendritic cells (DCs). To be able to investigate the biology of human cutaneous DCs, she has optimized the methods for isolation of viable and functional DC subsets from different human skin compartments. Employing a variety of approaches, including in vitro analysis of DC and T cell phenotype and function, transcriptome network reconstruction and in silico modelling Dr Polak investigates the individual roles of these cell types in regulation of human cutaneous immune responses and molecular mechanisms underpinning their function.

近期论文

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Human lung fibroblasts present bacterial antigen to autologous lung T helper cells - Hutton, Andrew J., Polak, Marta E., Spalluto, C. Mirella, Wallington, Joshua C., Pickard, Christopher, Staples, Karl J., Warner, Jane A. and Wilkinson, Tom M.A. Published:2017Publication:The Journal of ImmunologyVolume:198, (1)Page Range:110-118doi:10.4049/jimmunol.1600602PMID:27895174 In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children - Haw, Wei Yann, Polak, Marta, Mcguire, Carolann, Erlewyn-Lajeunesse, Michel and Ardern-Jones, Michael Published:2016Publication:Annals of Allergy, Asthma & ImmunologyVolume:117, (1)Page Range:61-66doi:10.1016/j.anai.2016.04.017PMID:27221062 OX40 regulatory T cells in cutaneous squamous cell carcinoma suppress effector T cell responses and associate with metastatic potential - Lai, Chester, August, Suzannah, Albibas, Amel, Behar, Ramnik, Cho, Shin-Young, Polak, Marta, Theaker, Jeff, Macleod, Amanda S., French, Ruth, Glennie, Martin, Al-Shamkhani, Aymen and Healy, Eugene Published:2016Publication:Clinical Cancer ResearchPage Range:1-42doi:10.1158/1078-0432.CCR-15-2614PMID:27034329 Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis - Lai, Chester, August, Suzannah, Behar, Ramnik, Polak, Marta, Ardern-Jones, Mike, Theaker, Jeff, Al-Shamkhani, Aymen and Healy, Eugene Published:2015Publication:The LancetVolume:385 Page Range:S59doi:10.1016/S0140-6736(15)60374-9PMID:26312881 Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies - White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane E., Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A. and Glennie, Martin J. Published:2015Publication:Cancer CellVolume:27, (1)Page Range:138-148doi:10.1016/j.ccell.2014.11.001PMID:25500122