Oreffo, Richard - University of Southampton

个人简介

He leads the Bone and Joint Research Group, a large multidisciplinary research group, focused on developing strategies to repair bone & cartilage and understanding bone development; including the role of epigenetics in musculoskeletal diseases with translation a key personal driver. To achieve these goals, he has brought together and developed teams of clinicians and life scientists (including materials scientists, mathematicians, bio-informaticians) over the last fifteen years. In 2014 his group conducted the first 3D titanium-bone stem cell impaction bone graft. His commitment to interdisciplinary research are exemplified by breakthrough publications on skeletal stem cells and nanotopography, bone regeneration as well as epigenetics in Osteoarthritis in Nature Materials, ACS Nano, Stem Cells, Small, Arthritis and Rheumatism and Advanced Materials. Richard has published more than 240 peer-reviewed papers (>9,000 citations; h-index 51 as of November 2015), 20 reviews and book chapters, holds 6 patents and has won a number of awards for his research. As Associate Dean for International and Enterprise, he has established a number of industrial linkages and international collaborations (Japan, Hong Kong, Taiwan, Australia, New Zealand as well as Europe) to aid the bone regeneration programmes. Richard serves / has served on a number of Research Council Committees, Industrial committees and international advisory boards, holds a number of visiting professorships, an adjunct chair at King Saud University and is on the editorial boards of five journals. In 2009, he was appointed a Fellow of the Institute of Biology and in 2015 he was awarded a Doctor of Science degree by the University of Oxford.

研究领域

The aim of the group is to understand the mechanisms of bone development, growth and regeneration, how these differ in skeletal abnormalities and diseases such as osteoporosis and osteoarthritis, and to what extent bone growth is programmed during fetal life. Thus research in Professor Oreffo’s group is primarily centered on harnessing the potential of skeletal stem cells (whether derived from embryonic or fetal and adult sources) for the development of unique tissue engineering approaches for new cartilage and bone formation for orthopedic application. In parallel we are interested in the role of fetal programming as a consequence of maternal nutritional challenges on bone cell differentiation, activity, potential and bone function with age. Skeletal Research - the potential of skeletal stem cells The requirement for new bone to replace or restore the function of traumatised or degenerated bone, or for the replacement of lost mineralised tissue as a consequence of increasing age is a major clinical and socio-economic need. To date, bone formation stimulation regimes, although attractive, have yet to demonstrate clinical efficacy.

近期论文

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Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency - Lee, Louisa C.Y., Gadegaard, Nikolaj, de Andrés, María C., Turner, Lesley-Anne, Burgess, Karl V., Yarwood, Stephen J., Wells, Julia, Salmeron-Sanchez, Manuel, Meek, Dominic, Oreffo, Richard O.C and Dalby, Matthew J. Published:2016Publication:BiomaterialsVolume:116Page Range:10-20doi:10.1016/j.biomaterials.2016.11.032 The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering. - Moreno-Jiménez, Ines, Hulsart Billstrom, Gry, Lanham, Stuart A., Janeczek, Agnieszka A., Kontouli, Nasia, Kanczler, Janos M., Evans, Nicholas D. and Oreffo, Richard O.C. Published:2016Publication:Scientific ReportsVolume:6, (32168)Page Range:1-12doi:10.1038/srep32168PMID:27577960 Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1) - Greenhough, Joanna, Papadakis, Manos, Cutress, Ramsey, Townsend, Paul, Oreffo, Richard and Tare, Rahul Published:2016Publication:Scientific ReportsPage Range:1-39doi:10.1038/srep33504 Quantification of intracellular payload release from polymersome nanoparticles - Scarpa, Edoardo, Bailey, Joanne L., Janeczek, Agnieszka, Stumpf, Patrick, Johnston, Alexander, Oreffo, Richard, Woo, Yin L., Cheong, Ying and Evans, Nicholas Published:2016Publication:Scientific ReportsVolume:6, (29460)Page Range:1-13doi:10.1038/srep29460 Dynamic surfaces for the study of mesenchymal stem cell growth through adhesion regulation - Oreffo, Richard Published:2016Publication:ACS NanoPage Range:1-13doi:10.1021/acsnano.6b01765PMID:27322014